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Updated: Sep 11, 2025

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
10:44

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs

Published on: May 15, 2019

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易布鲁替尼与莱纳利多米德 (Revlimid/Dexamethasone) 结合使用,治疗复发性/逆转性多发性骨髓瘤 (AFT-15)

Yvonne Efebera1, Vera Suman2, Shira Dinner3

  • 1MPH, OhioHealth, Columbus, OH 43214, USA, yvonne.efebera@ohiohealth.com.

Cancers
|August 14, 2025
PubMed
概括

这一第一阶段试验发现,在复发性/耐药性多发性髓瘤 (MM) 中,将利那利多米德 (LEN) 与易布鲁替尼 (IBR) 和德甲 (DEX) 结合使用是可行的. 该疗法显示出可管理的毒性,疾病进展是停止治疗的主要原因.

关键词:
伊布鲁丁尼布可以.莱纳利多胺的使用方法多发性骨髓瘤是多发性骨髓瘤的一种.复发性和耐火性多发性骨髓瘤

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