前列腺癌患者接受抗雄激素缺乏治疗的认知障碍:一个范围审查
João Vasco Barreira1,2, Pedro Barreira3, Gil Falcão4
1Universidade Católica Portuguesa, Faculty of Health Sciences and Nursing, Centre for Interdisciplinary Research in Health (CIIS), 1649-023 Lisboa, Portugal.
Cancers
|August 14, 2025
概括
前列腺癌的雄激素剥夺疗法 (ADT) 可能会导致认知变化,但证据不一致. 需要使用标准化方法进行进一步的研究,以了解ADT.
科学领域:
- 神经学 神经学
- 在瘤学瘤学.
- 认知科学 认知科学
背景情况:
- 安卓素剥夺疗法 (ADT) 是前列腺癌 (PCa) 的标准治疗方法.
- 人们担心ADT的潜在认知副作用和长期神经影响.
研究的目的:
- 进行范围审查,综合PCa患者ADT相关认知变化的证据.
- 识别受影响的认知领域,并突出现有研究中的差距.
主要方法:
- 在CINAHL,PubMed,Scopus和Web of Science中进行系统的文献搜索,遵循PRISMA-ScR指南.
- 包括在ADT治疗的PCa患者认知功能的RCT,队列,病例控制和横截面研究.
- 提取关于研究设计,认知评估,测量工具和发现的数据.
主要成果:
- 包括22项研究,展示了各种认知评估方法.
- 一些研究报告了ADT患者的认知障碍 (工作记忆,口头/视觉记忆,执行功能);另一些研究发现没有显著影响.
- 在PCa分期,研究设计,治疗方案,并发症,评估工具,样本大小和持续时间的异质性限制了最终的结论.
结论:
- 关于ADT相关认知功能障碍的证据是异质和矛盾的.
- 方法上的不一致性阻碍了可靠的结论;标准化的评估和纵向研究是必要的.
- 由于生存率的增加,应考虑对接受ADT的PCa患者进行常规认知监测.
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