乳腺癌早期治疗后的长期不良事件,重点关注BRCA突变人口
Berta Obispo1, Caroline Bailleux2, Blanca Cantos3
1Hospital Universitario Infanta Leonor, 28031 Madrid, Spain.
Cancers
|August 14, 2025
概括
长期不良事件显著影响乳腺癌幸存者的生活质量. 本综述详细介绍这些事件,重点关注早期乳腺癌 (eBC) 和BRCA突变,以指导临床护理.
科学领域:
- 在瘤学瘤学.
- 遗传学 遗传学 是一个
- 公共卫生 公共卫生
背景情况:
- 乳腺癌 (BC) 是全球女性最常见的癌症,通常需要多模式治疗.
- 患有早期BC (eBC) 的患者,特别是患有BRCA1/BRCA2 (gBRCAm) 突变的患者,可能需要具有独特副作用概况的积极疗法.
- 治疗的好处包括减少复发和死亡率,但长期不良事件会对幸存者的健康相关生活质量 (HRQoL) 产生负面影响.
研究的目的:
- 审查eBC患者的长期不良事件,包括风险因素,管理和预防.
- 探索治疗对gBRCAm患者HRQoL的影响.
- 为临床医生提供基于证据的指导,以优化治疗和改善EBC幸存者的长期结果.
主要方法:
- 关于早期乳腺癌的长期不良事件研究的文献综述.
- 对与治疗相关的不良事件的风险因素,管理和预防策略的分析.
- 检查关于治疗对gBRCAm患者HRQoL的影响的证据.
主要成果:
- 在eBC幸存者中,各种身体,功能,情绪和心理社会长期不良事件可能发生.
- gBRCAm患者往往需要更积极的治疗,可能会改变副作用概况并影响HRQoL.
- 了解和管理这些长期影响对于治疗决策和患者福祉至关重要.
结论:
- 长期不良事件对eBC幸存者来说是一个重大问题,影响了他们的HRQoL.
- 量身定制的管理和预防策略是必不可少的,特别是对于gBRCAm患者.
- 本综述提供了全面的概述,以帮助临床医生改善长期患者的治疗结果.
关键词:
(新) 辅助治疗治疗 (新) 辅助治疗这是一种BRCA突变.乳腺癌的生存率 乳腺癌的生存率优化癌症治疗优化癌症治疗乳腺癌的早期发展与健康相关的生活质量.长期不良事件 长期不良事件长期的毒性 长期的毒性更多相关视频
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