在接受异构血造干细胞移植的患者中,药物坚持
Hermioni L Amonoo1,2,3, Emma D Wolfe1, Emma P Keane1
1Brigham and Women's Hospital, Boston, MA 02115, USA.
Cancers
|August 14, 2025
概括
在血造干细胞移植 (HSCT) 后测量药物坚持是至关重要的. 客观方法和患者报告的方法显示差异很小,突出显示需要结合方法来评估HSCT患者的坚持.
科学领域:
- 血液学 血液学 血液学
- 药理学 药理学是指药理学的学科.
- 移植医学 移植医学
背景情况:
- 药物坚持对于血液造血干细胞移植 (HSCT) 的成功治疗和恢复至关重要.
- 关于HSCT患者有效的坚持测量方法和影响因素的数据有限.
研究的目的:
- 评估在接受全源性HSCT的患者中免疫抑制药物的坚持.
- 为了比较不同的粘附测量方法,并确定粘附的预测因素.
主要方法:
- 对150名患者进行血性恶性瘤全基性HSCT的前性纵向研究.
- 通过药丸计数,药物水平,患者日志 (剂量和时间) 和MARS-5在HSCT后的30,100和180天评估依从性.
- 卡帕分析用于评估测量方法之间的一致性.
主要成果:
- 根据测量类型,坚持率有很大的差异:药丸数量 (52-64%),药物水平 (18-24%),患者日志 (96-98%剂量,83-84%时间) 和MARS-5 (97-98%).
- 在客观和患者报告的遵守措施之间观察到的最小一致性 (卡帕范围:0.008-0.12).
- 患者报告的测量结果显示了很高的坚持,而客观的测量结果显示了更适度的坚持.
结论:
- 在HSCT患者中,客观和患者报告的坚持措施之间的差异是显著的.
- 药物治疗方案的复杂性可能会导致坚持测量的变化.
- 建议采用综合方法,将客观和主观措施结合起来,以准确评估HSCT中药物坚持.
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