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胰腺癌的新辅助疗法或前置手术 - 给谁,什么时候,如何?

Daria Kwaśniewska¹, Marta Fudalej^1,2, Anna Maria Badowska-Kozakiewicz²

¹Department of Oncology, National Medical Institute of the Ministry of the Interior and Administration, 02-507 Warsaw, Poland.

|August 14, 2025

概括

新辅助疗法 (NAT) 现在是边缘切除胰腺癌的标准. 对于可切除的胰腺癌,建议基于风险分层的个性化治疗,而免疫治疗则是建议的.

科学领域:

手术瘤学手术瘤学
胃肠病学胃肠病学
医学瘤学医学瘤学

背景情况:

对切除性胰腺管腺癌 (R-PDAC) 和边界切除性胰腺管腺癌 (BR-PDAC) 的管理进行了讨论.
新辅助疗法 (NAT) 在BR-PDAC中显示出好处,改善了切除能力和R0切除率.
在R-PDAC中NAT的作用和在PDAC中免疫治疗的作用需要进一步澄清.

研究的目的:

审查比较NAT与胰腺癌前期手术的证据.
为了确定NAT是否比术后策略提供生存优势.
为了确定从NAT中受益最多的临床场景.

主要方法:

随机对照试验和元分析的全面叙事审查.
在PubMed,Scopus和Google Scholar的系统文献搜索到2025年3月.
文章的选择遵循了PRISMA的准则.

主要成果:

新辅助疗法 (NAT) 被支持作为BR-PDAC的标准护理.
建议对R-PDAC进行个性化管理,以风险分层为指导.
免疫疗法和向疗法正处于PDAC的早期研究阶段.

结论:

NAT是边缘切除胰腺癌的护理标准.
切除胰腺癌的治疗应根据风险分层进行个性化.
免疫疗法在胰腺癌治疗中的作用仍在研究中.

关键词:

一个辅助的辅助者.边界切除可切除的这是一种新辅助剂.胰腺管道腺癌癌的癌症可切除的可切除物

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