炎症性关节炎中的生活质量和执行功能缺陷:风湿性关节炎和牛皮性关节炎的比较研究
Cigdem Cekmece1, Begum Capa Tayyare1, Duygu Temiz Karadag2
1Section of Occupational Therapy, Department of Therapy and Rehabilitation, Vocational School of Kocaeli Health Services, Kocaeli University, Umuttepe Campus, 41380 Izmit, Turkey.
类风湿性关节炎患者的执行功能和生活质量比牛皮性关节炎患者差. 类风湿性关节炎的执行功能障碍与疾病活动有关,并影响日常生活.
科学领域:
- 神经科学是一个神经科学.
- 类风湿病学 类风湿病学
- 心理学 心理学 心理学
背景情况:
- 执行功能 (EF) 对于管理关节炎等慢性疾病至关重要.
- 在关节炎患者中,EF损伤可能会影响治疗坚持,决策和应对策略.
研究的目的:
- 在类风湿性关节炎 (RA) 和牛皮性关节炎 (PsA) 患者之间比较执行功能,功能状态和生活质量.
- 研究RA和PSA的EF,疾病活性和临床变量之间的关联.
主要方法:
- 一项涉及140名患者 (70名RA,70名PsA) 的横截面研究.
- 使用Stroop-TBAG,WCST和ADEXI进行了EF评估.
- 测量功能状态 (HAQ) 和生活质量 (WHOQOL-BREF),与疾病活性相关 (DAS28-CRP),年龄和疾病持续时间.
主要成果:
- 与PSA患者相比,RA患者在EF测试 (Stroop,WCST,ADEXI) 上表现较差,疾病活性更高,持续时间更长,表现较差.
- 在RA中,疾病活性与EF损伤,残疾 (HAQ) 和生活质量降低相关.
- 在PsA中,EF是稳定的,但疾病活性与HAQ得分较差有关. 组合疗法与较低的生活质量和更高的HAQ相关.
结论:
- 类风湿性关节炎患者表现出比牛皮性关节炎患者更显著的执行功能障碍,更低的功能状态和更差的生活质量.
- 研究结果强调需要在炎症性关节炎,特别是RA中制定全面的评估策略,承认认知功能,日常生活和疾病负担之间的联系.
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