肠道菌群和营养状况在儿科芬基尿症:一个横截面试点研究
Malgorzata Ostrowska1, Elwira Komoń-Janczara1, Bozena Mikoluc2
1Department of Biotechnology, Microbiology and Human Nutrition, University of Life Sciences in Lublin, 20-704 Lublin, Poland.
Nutrients
|August 14, 2025
概括
与健康儿童相比,基尿症 (PKU) 患者表现出明显的肠道真菌特征,受其低氨酸食的影响. 这些肠道菌群的变化可能成为PKU营养和临床监测的重要生物标志物.
科学领域:
- 微生物组研究 微生物组研究
- 代谢障碍 代谢障碍 代谢障碍
- 儿童营养学 儿童营养学
背景情况:
- 基尿症 (PKU) 是一种终身代谢障碍,需要严格的低氨饮食.
- 在PKU中,饮食干预可以影响肠道微生物群,但真菌成分 (mycobiome) 尚未得到研究.
- 这项研究研究了儿科PKU患者与对照者的年龄分层肠道菌群组差异.
研究的目的:
- 为了比较儿科PKU患者和健康对照者的肠道菌群组成.
- 分析PKU患者的饮食特征及其与真菌种群的相关性.
- 探索与PKU管理相关的肠道菌群的年龄相关变异.
主要方法:
- 使用ITS1/ITS2 amplicon测序对20名儿童 (10名PKU,10名对照组) 的便样本进行分析.
- 通过BMI百分位数评估营养状况,并从饮食记录评估营养摄入量.
- 探索已识别的真菌种群与饮食因素之间的相关性.
主要成果:
- 在PKU患者和对照人群之间观察到不同的真菌社区结构 (β多样性),倾向于分离组.
- 与对照人群相比,PKU患者表现出Eurotiales和Aspergillaceae的丰度增加,Physalac পরিষ্কারaceae和Malassezia的丰度减少.
- 在PKU患者中,在Geotrichum和蛋白质/氨摄入量之间发现了显著的相关性.
结论:
- 饮食管理PKU与肠道真菌生物组的年龄相关变化有关.
- 在PKU患者中,特定真菌类 (例如,Eurotiales,Aspergillaceae,Penicillium) 的丰度增加可能与碳水化合物/脂质代谢和炎症有关.
- 肠道真菌在PKU中显示出作为有价值的营养和临床生物标志物的潜力.
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