相关实验视频

Updated: Sep 11, 2025

Novel Production Protocol for Small-scale Manufacture of Probiotic Fermented Foods

Novel Production Protocol for Small-scale Manufacture of Probiotic Fermented Foods

Published on: September 10, 2016

使用Lactobacillus kefiranofaciens HL1和Lactococcus lactis APL01515开发一种具有抗衰老和抗氧化性能的新型发酵牛奶

Sheng-Yao Wang¹, Wei-Chen Yen¹, Yen-Po Chen^2,3

¹Department of Animal Science and Technology, National Taiwan University, Taipei 10617, Taiwan.

|August 14, 2025

概括

这项研究使用共同培养的Lactobacillus kefiranofaciens HL1和Lactococcus lactis APL015开发了一种新的发酵牛奶,通过调节肠道微生物群和减少炎症,在小鼠中显示出显著的抗衰老和认知益处.

科学领域:

微生物学微生物学
食品科学食品科学食品科学
老年学是一门学科.

背景情况:

乳酸菌克菲拉诺法西恩斯HL1具有抗氧化和抗衰老的特性.
由于HL1的牛奶生存能力较差,因此限制了其作为功能性食品的应用.
与乳球菌乳酸菌亚种共同培养. 克雷莫里斯APL015增强发酵和健康益处.

研究的目的:

通过共同培养HL1和APL15.5来开发一种新的发酵牛奶.
评估新型发酵牛奶的发酵性能和健康益处.
评估D-银糖诱导的老化小鼠模型中发酵牛奶的抗衰老作用.

主要方法:

共同培养HL1和APL15以生产发酵牛奶 (FM).
评估发酵参数,微生物活力,纹理和协同作用.
在老年小鼠中评估认知功能,氧化应激,炎症和肠道微生物群,这些老鼠被食了FM.

主要成果:

FM实现了最佳的发酵,两种菌株的可生存数量都很高 (~10^9 CFU/mL).
在小鼠中,FM表现出改善的认知行为,减少氧化应激标志物 (MDA) 和降低炎症类细胞因子 (IL-1β,TNF-α).
FM的使用增加了有益的肠道细菌,甲酸,并增强了大脑抗氧化酶活性 (SOD).

结论:

共同培养的发酵牛奶有效地提供HL1并具有抗氧化,抗炎和抗衰老作用.
观察到的好处很可能是通过肠-大脑轴调节的介导.
这种新的发酵牛奶显示出作为促进健康衰老的功能性食品的潜力.

关键词:

D-银糖的衰老过程乳酸菌克菲拉诺法西恩斯 (Lactobacillus kefiranofaciens) 是一种乳球球菌 (lactococcus lactis) 是一种乳球菌.发酵牛奶发酵牛奶是什么意思肠大脑轴肠大脑轴这是一种炎症炎症炎症炎症.氧化应激是一种氧化应激.益生菌是一种益生菌.

更多相关视频

The Cultivation, Growth, and Viability of Lactic Acid Bacteria: A Quality Control Perspective

The Cultivation, Growth, and Viability of Lactic Acid Bacteria: A Quality Control Perspective

Published on: June 16, 2022

Author Spotlight: Process Development for the Spray-Drying of Probiotic Bacteria and Evaluation of the Product Quality

Author Spotlight: Process Development for the Spray-Drying of Probiotic Bacteria and Evaluation of the Product Quality

Published on: April 7, 2023

相关概念视频

Fermentation

Fermentation

Most eukaryotic organisms require oxygen to survive and function adequately. Such organisms produce large amounts of energy during aerobic respiration by metabolizing glucose and oxygen into carbon dioxide and water. However, most eukaryotes can generate some energy in the absence of oxygen by anaerobic metabolism.
Fermentation is a type of metabolic process that occurs in the absence of oxygen, where organic molecules such as glucose are broken down to produce energy. During this process, the...

Microbial Fermentation

Microbial Fermentation

Fermentation is a crucial anaerobic metabolic process that enables microbes to derive energy from sugar without relying on oxygen or an electron transport chain. This process is fundamental to various biological and industrial applications and is classified based on the metabolic products generated.Role of Pyruvate in FermentationPyruvate and its derivatives serve as key electron acceptors in fermentative pathways. The oxidation of NADH to regenerate NAD+ is essential for the continuation of...

Microorganisms in Agriculture and Food industry

Microorganisms in Agriculture and Food industry

Microorganisms play a crucial role in agriculture and the food industry, contributing to soil fertility, crop protection, and food production. Their functions range from nitrogen fixation and biopesticide production to fermentation and food preservation, making them indispensable to sustainable farming and food safety.Role in AgricultureNitrogen-fixing bacteria, such as Rhizobium (symbiotic) and Azotobacter (free-living), convert atmospheric nitrogen into ammonia through biological nitrogen...