益生菌对尿酸水平的影响:元分析与子组分析和元回归
Rym Ben Othman1,2, Mouna Ben Sassi2,3,4, Syrine Ben Hammamia2,3,4
1Institut National de Nutrition et de Technologie Alimentaire de Tunis, 11 Rue Jbal Lakhdhar, Tunis 1007, Tunisia.
Nutrients
|August 14, 2025
概括
益生菌显著降低了尿酸水平在患有疾病的患者的元分析. 这种效应在接受特定单列益生菌治疗的亚洲男性中最为明显.
科学领域:
- 微生物学 微生物学
- 人体生理学 人体生理学
- 营养科学 营养科学
背景情况:
- 众所周知,益生菌会影响肠道微生物群的组成.
- 益生菌对微生物群的调节可能会影响系统代谢标记物.
- 以前的研究表明,益生菌在控制尿酸水平方面可能发挥作用.
研究的目的:
- 进行一项元分析,评估益生菌在降低尿酸水平方面的有效性.
- 为了确定特定的患者群体或与尿酸减少相关的益生菌特征.
主要方法:
- 在主要数据库 (PubMed,EMBASE,Web of Science,Google Scholar) 中系统地搜索相关研究的文献.
- 包括2000年1月至2024年8月期间发表的随机对照试验和观察性研究,比较益生菌与安慰剂.
- 独立审稿人进行数据提取和质量评估,遵循PRISMA 2020和AMSTAR 2指南.
主要成果:
- 包括9项包括394名患者 (201名益生菌,193名安慰剂) 的研究.
- 与安慰剂相比,在益生菌组观察到尿酸水平的统计显著降低.
- 亚组分析确定了大陆,疾病状况,男性性别和单列益生菌作为这种效应的显著调节者.
结论:
- 益生菌在降低尿酸水平方面表现出显著的影响.
- 这种有益的效果在亚洲男性中尤其明显,这些男性有现有的疾病条件.
- 用单列益生菌治疗似乎是实现尿酸减少的关键因素.
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