自闭症谱系障碍:从实验模型到益生菌的应用,特别关注Lactiplantibacillus plantarum
Giusi Sabatini1, Ilenia Boccadoro1, Roberta Prete1
1Department of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, 64100 Teramo, Italy.
Nutrients
|August 14, 2025
概括
益生菌补充剂,特别是Lactiplantibacillus plantarum,显示出改善自闭症谱系障碍 (ASD) 的胃肠道和行为症状的希望. 需要进一步的研究来确认疗效并建立最佳的方案.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 胃肠病学 胃肠病学
背景情况:
- 自闭症谱系障碍 (ASD) 是一种复杂的神经发育状况,受遗传和环境因素的影响.
- 已知的促成因素包括炎症,内分泌系统和肠道微生物群的改变.
- 对于自闭症的确切病原发生原因仍然不完全理解.
研究的目的:
- 审查ASD研究中使用的小鼠模型.
- 确定用于ASD诊断的关键生物标志物.
- 评估益生菌的治疗潜力,特别是乳酸植物菌植物菌,在ASD.
主要方法:
- 现有研究的系统文献审查.
- 对ASD常用的小鼠模型的分析.
- 对生物标志物和益生菌干预的研究 in vivo 和临床试验.
主要成果:
- 针对多因素生物标志物有助于理解ASD机制.
- 益生菌,包括Lpb. 足部,表现出有益的影响.
- 益生菌在调节肠-大脑轴通信方面显示出潜力.
结论:
- 乳植物菌种 (Lactiplantibacillus plantarum) 的菌株显示出作为治疗自闭症症状的补充疗法的前景.
- 益生菌补充剂可能有助于改善与ASD相关的胃肠道和行为问题.
- 需要进行大规模的临床研究来验证疗效并优化治疗策略.
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