麦纤维通过调节肠道屏障功能来缓解小鼠的洛帕胺诱导的便秘
Yufei Shi1, Yuchao Han1, Jie Jiang1
1Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, No. 87, Dingjiaqiao, Gulou District, Nanjing 210009, China.
Nutrients
|August 14, 2025
概括
麦纤维通过改善肠道微生物群,调节胃肠道和减少炎症,有效地缓解小鼠的便秘. 这种饮食干预可以增强肠道功能和屏障完整性.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 营养科学 营养科学
背景情况:
- 便秘是一种常见的胃肠道疾病,对生活质量产生重大影响.
- 食纤维,特别是麦纤维,因其在管理消化健康方面的潜在作用而得到认可.
- 了解麦纤维影响肠道功能的机制对于治疗开发至关重要.
研究的目的:
- 在小鼠模型中研究麦纤维在缓解洛佩拉胺诱导的便秘方面的有效性.
- 阐明麦纤维对胃肠道生理和微生物群的作用的基本机制.
主要方法:
- 雄性BALB/c小鼠使用洛佩拉米德诱导便秘.
- 麦纤维在21天内以低,中,高剂量进行胃内注射.
- 评估的关键参数包括便输出,肠道运输,胃肠道水平,肠道微生物群组成和炎症标志物.
主要成果:
- 麦纤维显著增加了便产量和水含量,并改善了肠道过渡时间.
- 它调节了胃肠道,包括对莫提林 (MTL) 和胃素 (GAS) 的上调和对血管活性肠道 (VIP) 和体静止素 (SS) 的下调.
- 麦纤维降低了炎症标志物 (TNF-α,IL-1β),降低了Aquaporin 8 (AQP8) 表达,并增强了肠道微生物群的多样性,有利于Firmicutes而不是Bacteroidetes.
结论:
- 麦纤维在改善小鼠便秘方面表现出显著的有效性.
- 它的治疗作用通过调节胃肠调节,增强肠道微生物群,减少肠道炎症和屏障损伤来调节.
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