新生儿的粘液囊养:为什么,什么时候,如何,在哪里? 来自系统审查的见解
Layla Musleh1,2, Ilaria Cozzi3, Anteo Di Napoli4
1Department of Public Health and Infectious Disease, Sapienza University of Rome, 00185 Rome, Italy.
Nutrients
|August 14, 2025
概括
粘膜囊再养 (MFR) 显著改善体重增加,并减少婴儿的肠道营养 (PN) 持续时间. 虽然MFR在新生儿护理中提供了好处,但需要标准化的协议来确保其安全性和有效性.
科学领域:
- 新生儿手术 新生儿手术
- 儿科胃肠病学 儿科胃肠病学
- 临床营养学 临床营养学
背景情况:
- 患有高输出肠静脉切除术的婴儿通常需要长时间的肠外营养 (PN),导致感染和生长障碍等风险.
- 粘膜囊再养 (MFR) 是一种旨在改善这些婴儿的肠道适应,体重增加和远端肠道成熟的技术.
研究的目的:
- 系统地审查和元分析婴儿粘膜囊再养 (MFR) 的有效性,安全性和技术方面.
- 为了比较接受MFR和不接受MFR的婴儿之间的结果.
主要方法:
- 按照PRISMA指南进行系统审查和元分析,包括没有数据或语言限制的研究.
- 数据从多个数据库中提取 (PubMed,EMBASE,CINAHL,Scopus,科学网,科克兰图书馆,UpToDate).这些数据可以从多个数据库中提取.
- 使用Joanna Briggs研究所批判性评估检查清单评估偏差风险;元分析使用随机和固定效应模型.
主要成果:
- 包括17项研究,涉及631名婴儿 (482名MFR,149名非MFR).
- MFR显著改善体重增加 (4.7g/天而不是24.2g/天) 和减少PN持续时间 (60.3天而不是95天).
- MFR与更短的住院和NICU停留时间以及更低的胆固醇病变风险 (OR 0.151) 相关.
结论:
- 粘膜囊再养 (MFR) 对需要亲肠道营养的婴儿具有显著的益处,包括改善体重增加和减少养时间.
- 尽管有好处,但MFR实践是异质的,强调需要标准化的协议来优化新生儿护理的安全性和有效性.
- 虽然MFR与胆固醇降低有关,但诸如败血症和肠道穿孔等并发症需要仔细监测.
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