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在胃癌细胞上的Vitex agnus-castus种子提取物的抗癌活性

Özlem Türksoy-Terzioğlu^1,2, Feyza Tosya^2,3, Ayşe Büşranur Çelik^1,2

¹Department of Molecular Biology and Genetics, Hamidiye Institute of Health Sciences, University of Health Sciences-Turkey, Istanbul 34668, Türkiye.

|August 14, 2025

概括

维泰克斯 (Vitex agnus-castus) 种子提取物对胃癌细胞表现出强大的抗癌作用. 它有效地降低了细胞活力,促进了细胞亡,并抑制了癌细胞迁移,这表明了临床潜力.

科学领域:

植物化学植物化学
癌症生物学癌症生物学
药理学药理学是指药理学的学科.

背景情况:

传统上,Vitex agnus-castus (VAC) 是用于治疗荷尔蒙障碍的药物.
新出现的证据表明,VAC的潜在抗癌性质.
VAC对胃癌的影响在很大程度上仍未被探索.

研究的目的:

研究VAC种子提取物对胃癌细胞的细胞毒性,亡性和抗转移性作用.
分析VAC提取物的抗氧化能力和植物化学含量.
阐明VAC的抗癌活性背后的分子机制.

主要方法:

制备和分析了含有抗氧化剂活性 (DPPH,ABTS) 和植物化学物质的液醇VAC种子提取物.
在胃癌细胞系 (HGC27,MKN45,AGS) 和纤维细胞中使用MTT测定来评估细胞毒性.
评估了细胞亡,线粒体膜潜力 (MMP),细胞周期,基因表达 (RT-qPCR),蛋白质表达 (ELISA),迁移和上皮-介质细胞转变 (EMT) 标记.

主要成果:

VAC提取物表现出显著的抗氧化活性和丰富的和黄含量.
它在胃癌细胞中表现出剂量依赖的细胞毒性,对纤维细胞的毒性最小.
提取物诱导了亡,G0/G1细胞周期停止,破坏了MMP,抑制了迁移和EMT,并调节了与亡相关的关键基因和蛋白质.

结论:

维泰克斯 (Vitex agnus-castus) 种子提取物对抗胃癌具有显著的抗癌特性.
提取物通过诱导亡,抑制增殖和抑制转移而起作用.
建议进行进一步的研究,以探索VAC在胃癌治疗中的临床应用.

关键词:

维泰克斯 (Vitex agnus-castus) 是一种植物.灭症 (apoptosis) 是一种死亡的过程.细胞毒性细胞毒性表皮介酶过渡 (EMT) 发生.胃癌胃癌是一种胃癌.

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