20岁后自我报告的体重增加和肥胖性肝病的风险
Masayo Iwasa1, Naoki Ozu1,2, Hajime Yamakage1,3
1Department of Endocrinology, Metabolism and Hypertension Research, Clinical Research Institute, NHO Kyoto Medical Center, 1-1 Fukakusa Mukaihata-cho, Fushimi-ku, Kyoto 612-8555, Japan.
Nutrients
|August 14, 2025
概括
20岁以后显著的体重增加,特别是10公斤或更多,是发展肝脂肪症 (脂肪肝疾病) 的关键指标. 这一发现有助于识别患脂肪肝疾病的风险较高的人,即使没有高基线BMI.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 肝硬化,或脂肪肝病,是一般人群日益严重的健康问题.
- 早期识别风险因素对于预防策略和管理疾病至关重要.
研究的目的:
- 确定特定的问卷单项是否可以预测患肝硬化症的风险.
- 调查不同类别的体重指数 (BMI) 之间自我报告的体重增加和发生的肝肥胖症之间的关联.
主要方法:
- 一组15,063名没有基线肝硬化症的成年人被随访了平均4.2年.
- 关于生活方式因素的问卷调查数据,包括体重史,在基线收集.
- 统计分析,包括危险比率,用于评估与调查问卷项目相关的风险,调整为混因素.
主要成果:
- 在随访期间,12.5%的队列在随访期间发展出肝肥胖症.
- 20岁后自报的体重增加10公斤或以上是发展肝肥胖症的最强预测因素 (HR 2.11,p < 0.001).
- 这一关联在所有BMI类别中仍然显著,包括那些BMI正常的人.
结论:
- 自我报告的体重增加20岁以后10公斤或以上是一个显著的,独立的风险因素发展肝硬化症.
- 将关于体重增加史的问题纳入健康问卷中,可以帮助识别患有脂肪肝疾病风险较高的人.
- 这些发现支持在一般人群中使用简单的基于问卷的查来评估脂肪肝疾病的风险.
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