探索多维饮食模式与使用孟德尔随机化的非痕脱发之间的关联
Lingfeng Pan1, Philipp Moog1, Caihong Li2
1Clinic for Plastic, Reconstructive and Hand Surgery, Klinikum Rechts der Isar, Technical University of Munich, 81675 Munich, Germany.
Nutrients
|August 14, 2025
概括
饮食习惯会影响脱发. 富含抗氧化剂的食物,如茶,可以防止白发性脱发 (AA) 和雄原性脱发 (AGA),而酒精会增加风险. 定制饮食可以帮助控制脱发.
科学领域:
- 营养科学 营养科学
- 遗传学 是一个遗传学.
- 皮肤病学 皮肤病学
背景情况:
- 雄激素性脱毛症 (AGA) 和脱毛区域性脱毛症 (AA) 导致显著的心理社会痛苦.
- 由于观察性研究的局限性,饮食因素在脱发中的作用尚未得到充分研究.
- 门德尔随机化 (MR) 可以解决饮食暴露研究中的混偏见.
研究的目的:
- 调查187种饮食暴露和无痕脱发 (AA和AGA) 之间的因果关系.
- 为了利用遗传变异进行强大的推断,克服传统观测研究的局限性.
主要方法:
- 利用了来自161,625名英国生物库参与者的全基因组关联研究 (GWAS) 数据.
- 对于187种通过饮食暴露的全基因组显著性 (p < 5 × 10−8) 的精选遗传仪器.
- 进行了严格的敏感性分析 (MR-Egger,MR-PRESSO) 并分析了来自FinnGen.GA的AA/AGA数据集.
主要成果:
- 确定了18种与脱发显著相关的饮食暴露 (FDR <0.05).
- 富含抗氧化剂的食物 (西瓜,洋,茶) 显示有保护作用.
- 与红,山羊奶酪,全脂牛奶相关的风险增加;酒精是AA和AGA的强有力的风险因素.
结论:
- 饮食模式是脱发的可改变因素.
- 建议采取一种战略,优先考虑富含多的植物性食品,并尽量减少促炎触发因素 (加工碳水化合物,酒精).
- 饮食调整,包括减少超加工食品和酒精摄入量,可以补充现有的脱发疗法.
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