在等离子激活合金表面上涂上抗菌和抗真菌的酸涂层
Mariusz Winiecki1, Magdalena Stepczyńska2, Maciej Walczak3
1Department of Constructional Materials and Biomaterials, Faculty of Materials Engineering, Kazimierz Wielki University, 30 Chodkiewicza Street, 85-064 Bydgoszcz, Poland.
International journal of molecular sciences
|August 14, 2025
概括
植入物上的抗微生物酸涂层可以防止感染. 含有5%或更多酸的等离子激活对细菌和真菌具有广泛的疗效,增强生物相容性,以获得更好的植入结果.
科学领域:
- 生物材料科学 生物材料科学
- 表面工程是什么?表面工程是什么?
- 预防传染病 预防传染病
背景情况:
- (Ti) 合金由于其生物相容性,对骨科和牙科植入物至关重要.
- Ti植入物的一个主要局限性是它们对感染的易感性,增加了并发症风险.
- 抗微生物涂层提供了一种解决方案,以减轻植入物相关的感染.
研究的目的:
- 开发和评估等离子体激活 (Ti) 合金表面的酸 (TA) 涂层.
- 评估这些TA涂层Ti植入物的抗菌疗效和细胞相容性.
- 研究TA涂层在减少植入物相关感染方面的潜力.
主要方法:
- 使用低温氧气等离子体激活合金表面.
- 坦尼酸 (TA) 涂层通过浸泡应用在2%,5%和8%的度.
- 鉴定包括SEM,XPS,WCA和Folin-Ciocalteu测定;进行了体外细胞兼容性和抗菌试验.
主要成果:
- 形成了统一的TA层,通过增加TA度来增强表面的水友性.
- 甲酸释放谱显示了最初的爆发,随后持续扩散.
- 含有≥5%TA的涂层对大肠杆菌,金黄色杆菌,P. aeruginosa具有显著的杀菌活性,对C. albicans具有抗真菌作用.
- 所有TA涂层与纤维细胞细胞相容,水解产物促进细胞增殖.
结论:
- 用酸涂覆≥5%重量的等离子激活Ti表面提供广泛的抗菌活性.
- 这些TA涂层具有显著的潜力,可以减少植入物相关的感染.
- 开发的涂层可以改善骨科和牙科植入物的长期结果.
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