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维生素D,肠道微生物群和癌症免疫疗法 - - 一种潜在有效的交叉连接
Yizhen Yan1,2, Yi Guo2, Yiting Li2
1Beijing Key Laboratory of Sports Performance and Skill Assessment, Beijing Sport University, Beijing 100084, China.
International journal of molecular sciences
|August 14, 2025
概括
维生素D (VD) 通过调节肠道微生物群和免疫细胞,影响癌症免疫治疗. 最佳的VD水平可能会改善结果,但复杂的相互作用和剂量依赖性需要进一步研究以进行个性化治疗.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 在瘤学瘤学.
背景情况:
- 癌症免疫疗法显示出有希望的结果,但有效性各不相同.
- 肠道微生物群和维生素D (VD) 是治疗反应的新兴调节剂.
- 静脉疾病在癌症免疫治疗中的作用及其与肠道微生物群的相互作用是复杂的和有争议的.
研究的目的:
- 系统地回顾VD,肠道微生物群和癌症免疫治疗之间的相互作用.
- 阐明VD影响抗瘤免疫力的机制.
- 分析关于静脉疾病对免疫治疗结果和毒性影响的临床数据.
主要方法:
- 对同行评审证据的系统性文献审查.
- 搜索的数据库:PubMed,Scopus,科学网,PsycINFO,MEDLINE (2000年1月至2025年5月) 搜索的数据库:PubMed,Scopus,科学网,PsycINFO,MEDLINE (2025年1月至5月) 搜索的数据库:PubMed,Scopus,PsycINFO,MEDLINE (2025年1月至5月) 搜索的数据库:PubMed,Scopus,Web of Science,PsycINFO,MEDLINE (2025年1月至5月) 搜索的数据库:PubMed,Scopus,Web of Science,PsycINFO,MEDLINE (2025年1月至5月) 搜索的数据库:
- 对静脉疾病的免疫调节作用,肠道微生物群相互作用和临床结果的分析.
主要成果:
- 通过VDR信号和肠道微生物群调节,VD表现出双重的免疫调节效应.
- 临床数据显示了有关静脉疾病水平和免疫治疗反应的矛盾结果.
- 静脉疾病和微生物群之间存在双向关系,影响免疫反应和静脉疾病代谢.
结论:
- 血管疾病在癌症免疫治疗中的作用是复杂的,受到剂量和微生物群相互作用的影响.
- 需要进一步的研究,以了解静脉疾病的剂量依赖和微生物群介导机制.
- 个性化策略和临床试验对于优化静脉疾病在精密免疫治疗中的使用至关重要.
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