在自闭症谱系障碍中的系统性尿素毒素负担:分层化尿代谢物分析
Joško Osredkar1,2, Teja Fabjan1, Uroš Godnov3
1Institute of Clinical Chemistry and Biochemistry, University Medical Centre Ljubljana, Zaloška Cesta 2, 1000 Ljubljana, Slovenia.
International journal of molecular sciences
|August 14, 2025
概括
自闭症谱系障碍 (ASD) 与肠道微生物的变化有关. 尿道毒素的功能比率,而不仅仅是水平,揭示了ASD儿童的代谢平衡变化.
科学领域:
- 微生物学 微生物学
- 代谢学 代谢学 代谢学
- 神经发育障碍 神经发育障碍
背景情况:
- 自闭症谱系障碍 (ASD) 越来越多地与肠道微生物和代谢障碍有关.
- 改变肠道产生的尿性毒素的产生是这些代谢变化的关键特征.
研究的目的:
- 研究与健康对照组相比,ASD儿童中五种主要尿性毒素的尿度和功能比率.
- 探索这些毒素的特征是如何根据性别,年龄和自闭症严重程度而有所不同.
主要方法:
- 在161名患有自闭症儿童和71名使用LC-MS/MS的对照组中,测量了尿中氧化硫酸 (IS),p-cresyl硫酸 (PCS),三甲基胺N氧化物 (TMAO),非对称二甲基氨基酸 (ADMA) 和对称二甲基氨基酸 (SDMA).
- 毒素度与肌素的正常化以及分析的个体水平,总负担,比例贡献和功能比率 (IS/PCS,PCS/TMAO,IS/ADMA).
- 根据性别,年龄组和自闭症严重程度进行了子组分析 (儿童自闭症评分表 - CARS).
主要成果:
- 单个毒素度在ASD和对照组之间没有显著差异.
- 分层分析显示,PCS在女孩和严重的ASD病例中较高;IS和TMAO在更年轻和更严重的ASD病例中减少.
- 功能比率随着自闭症严重程度的显著变化:IS/PCS下降,PCS/TMAO增加,表明具有主导的微生物特征和改变宿主微生物平衡.
结论:
- 尿尿性毒素概况,特别是功能比率,为ASD中的代谢障碍提供了比单个度更敏感的标志物.
- 这些发现表明ASD的宿主微生物代谢平衡发生变化,其特征是具有主导的微生物特征.
- 功能性毒素分析可能会提高对自闭症谱系障碍中代谢变化的表征和理解.
关键词:
ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was that was was was was was was was was was was was was was was was was was was was was was was was that was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was这就是TMAOO.自闭症谱系障碍 自闭症谱系障碍我们的肠道微生物群.硫酸印氧基硫酸盐的使用方法代谢生物组的代谢生物组在p-cresyl硫酸盐中.尿源性毒素是一种毒素.尿路生物标志物
