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在老鼠的Roux-en-Y胃绕道后,局部特异性肠道微生物组的变化:多组分牛乳基复合体的影响
Zhanagul Khassenbekova1, Kadyrzhan Makangali2, Aruzhan Shoman2
1Innovative Center ArtScience, Astana Z00T3X6, Kazakhstan.
International journal of molecular sciences
|August 14, 2025
概括
在Roux-en-Y胃绕道 (RYGB) 手术中,肠道微生物在区域范围内发生变化. 一种牛乳-蜂蜜-服务 (CHJ) 综合体显示出混合作用,恢复了一些有益的细菌,但增加了其他细菌,影响了代谢结果.
科学领域:
- 胃肠病学 胃肠病学
- 微生物组研究 微生物组研究
- 代谢手术 代谢手术
背景情况:
- 鲁克斯-en-Y胃旁路手术 (RYGB) 显著改变了肠道微生物群,可能会影响代谢健康.
- 了解RYGB后特定地点的微生物变化对于开发有针对性的干预措施至关重要.
研究的目的:
- 在肥胖大鼠中研究牛乳-蜂蜜-服务 (CHJ) 综合体在RYGB后对肠道微生物群的特定场所影响.
- 分析CHJ补充剂对不同胃肠道段的粘膜相关微生物群和血清代谢物的影响.
主要方法:
- 威斯塔大鼠接受了RYGB手术,有或没有CHJ补充剂.
- 用5个胃肠道段的16SrRNA测序分析了粘膜相关的微生物群.
- 进行血清代谢物概况分析以评估代谢变化.
主要成果:
- RYGB诱导区域性失调,其特点是α多样性减少,十二指肠中蛋白质菌增加,SCFA产生细菌减少.
- 补充CHJ有双重效应:远距离恢复有益细菌 (乳酸菌,双菌),而近距离增加肠杆菌.
- 尽管预测胺通路激活,但观察到显著的血清维生素B1减少,这表明吸收缺陷.
结论:
- 后RYGB肠道失调症表现出显著的区域异质性,需要针对特定细分的干预措施.
- 像CHJ这样的营养补充剂可以调节RYGB后的肠道微生物群,但具有复杂的,特定地点的结果.
- 该研究强调了手术改变,肠道生态和营养支持之间的复杂相互作用,以确定代谢健康.
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