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Updated: Sep 11, 2025

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
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A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators

Published on: February 20, 2018

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葡萄糖类-1受体 (GLP-1R) 信号传导:为功能性Gs蛋白选择性GPCR做出理由

Anastasios Lymperopoulos1, Victoria L Altsman1, Renee A Stoicovy1

  • 1Laboratory for the Study of Neurohormonal Control of the Circulation, Department of Pharmaceutical Sciences (Pharmacology), Barry and Judy Silverman College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL 33328-2018, USA.

International journal of molecular sciences
|August 14, 2025
PubMed
概括

葡萄糖类-1受体 (GLP-1R) 激动剂显示治疗成功. 有证据表明GLP-1R作为Gs选择性受体起作用,与GIPR不同,影响肥胖和糖尿病的药物开发.

关键词:
在G蛋白信号传递方面.作为一种强度激进剂,它具有强度激进剂.有偏见的信号传输.循环的腺单酸盐.脱敏感化 脱敏感化葡萄糖家族受体的多动因子分子.类似葡萄糖的-1受体受体.葡萄糖依赖的胰岛素受体受体贝雷斯的信号传递方式

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