后生菌beLP-K在甲诱导的萨尔科佩尼亚模型中的Lactobacillus plantarum的保护效率

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Juyeong Moon¹, Jin-Ho Lee¹, Eunwoo Jeong¹

¹Division of Biological Science and Technology, Yonsei University, Wonju 26493, Republic of Korea.

International journal of molecular sciences

|August 14, 2025

概括

热杀死的植物乳杆菌后生物 beLP-K 防止了肉病模型的肌肉损失. 它减少了肌肉蛋白质降解标记物,改善了肌肉质量和力量,这表明它有可能作为预防萨科佩尼亚的功能性食物.

科学领域:

肌肉生理学肌肉生理学
微生物学微生物学
老年学是一门学科.

背景情况:

肌肉质量和功能的减少,影响老年人,并可能被葡萄糖皮质激素恶化.
葡萄糖皮质类药物治疗可能会加剧肌肉蛋白质的分解,导致肉症的发展.

研究的目的:

评估热杀死乳酸菌植物后生物beLP-K对德克萨米他诱导的肉的预防作用.
阐明beLP-K在肌肉细胞和动物模型中的作用的潜在机制.

主要方法:

在体外研究中,使用暴露于德甲 (DEX) 的C2C12菌根管.
在体内研究中,使用了患有DEX诱导的肉症的斯普拉格-道利大鼠.
细胞毒性,肌肉蛋白降解标志物 (FoxO3α,MAFbx/atrogin-1,MuRF1),体重,握力和肌肉质量通过微型计算机断层扫描的评估.

主要成果:

beLP-K 没有表现出细胞毒性,并且保护了C2C12神经管免受DEX诱导的损伤.
beLP-K显著降低了关键肌肉缩标志物的表达 (FoxO3α,MAFbx/atrogin-1,MuRF1).
在大鼠中,beLP-K的使用抵消了DEX诱导的体重减轻,增加肌肉质量和改善握力.

结论:

在体外和体内,热杀死的 Lactobacillus plantarum 后生物 beLP-K 有效地预防和减轻德克萨米他诱导的肉症.
beLP-K的机制涉及抑制肌肉蛋白降解途径.
beLP-K 显示出作为治疗萨尔科佩尼亚的治疗剂或作为功能性食品成分的前景.

关键词:

在FoxO3α.乳酸菌植物植物 (Lactobacillus plantarum) 是一种植物菌.在MAFbx/atrogin-1中使用.MuRF1RF1 的使用情况成为LP-KK的德克萨米他是一种后生物的后生物的生物.这种类型的麻症是sarcopenia.

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