相关实验视频

Updated: Sep 11, 2025

Quantification of Hypopigmentation Activity In Vitro

Quantification of Hypopigmentation Activity In Vitro

Published on: March 6, 2019

通过白色木果提取物抑制铁酶和黑色素生成

Nuttawadee Prasawang¹, Nareerat Sutjarit², Athisri Sitthipunya¹

¹Department of Pathobiology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.

International journal of molecular sciences

|August 14, 2025

概括

白木提取物有效地抑制铁酶和黑色生成,防止UVB辐射引起的皮肤变黑. 这种天然化合物对化品应用有前途,其目标是高颜色.

科学领域:

皮肤病学和化学
生物化学和分子生物学

背景情况:

紫外线B (UVB) 辐射刺激黑色素的过度生产,导致多颜色和增加黑色素瘤的风险.
铁酶是黑色素发生的关键酶;其抑制是皮肤亮化剂的目标.
白色木 (Morus alba L.) 提取物以抗氧化特性和化品用途而闻名,但它们在UVB下的抗黑色素效应尚未得到研究.

研究的目的:

为了研究木原料提取物 (MCE) 抑制UVB诱导的黑色素发生的疗效.
在细胞和体内模型中评估MCE对铁酶活性的影响.
评估MCE作为天然皮肤亮化剂的安全性和潜力.

主要方法:

在B16F10黑色素瘤细胞中评估UVB辐射诱导的黑色素发生和铁酶活性.
使用斑马鱼胚胎作为体内模型来评估MCE的影响.
确定MCE的剂量依赖性影响和细胞毒性.

主要成果:

在剂量取决的方式上,MCE显著降低了铁酶活性和黑色素的产生.
没有观察到细胞毒性,表明了有利的安全性.
在MCE中的抗氧化成分可能是对观察到的抗黑色素效应负责.

结论:

树原料提取物是一种强大的UVB诱导的铁酶活性和黑色素生成的抑制剂.
MCE显示出作为一种安全有效的天然成分,可以预防皮肤多颜色的潜力.
对MCE的特定活性化合物和机制进行进一步研究是有必要的.

关键词:

B16F10 细胞 B16F10 细胞紫外线 (UVB) 辐射是什么?黑色素的产生是黑色素的产生.桑原油提取物桑原油提取物铁酶抑制的抑制作用一个斑马鱼胚胎.

更多相关视频

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

Published on: September 7, 2013

Y-27632 Enriches the Yield of Human Melanocytes from Adult Skin Tissues

Y-27632 Enriches the Yield of Human Melanocytes from Adult Skin Tissues

Published on: July 8, 2020

相关概念视频

Pigmentation

Pigmentation

The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...

Epistasis

Epistasis

In addition to multiple alleles at the same locus influencing traits, numerous genes or alleles at different locations may interact and influence phenotypes in a phenomenon called epistasis. For example, rabbit fur can be black or brown depending on whether the animal is homozygous dominant or heterozygous at a TYRP1 locus. However, if the rabbit is also homozygous recessive at a locus on the tyrosinase gene (TYR), it will have an unshaded coat that appears white, regardless of its TYRP1...