黑山青少年中氧化压力与心血管风险之间的关系
Aleksandra Klisic1,2, Marija Bozovic3, Barbara Ostanek4
1Faculty of Medicine, University of Montenegro, 81000 Podgorica, Montenegro.
International journal of molecular sciences
|August 14, 2025
概括
氧化应激标志物与青少年的心血管风险相关. 这表明将氧化还原状态纳入风险评估,以便在年轻人群中更好地预测心血管疾病.
科学领域:
- 心血管科学 心血管科学
- 生物化学 生物化学
- 青少年健康 青少年健康
背景情况:
- 氧化应激和心血管疾病 (CVD) 之间的联系尚未完全理解,特别是在青少年中.
- 氧化应激在心血管疾病的病理生理学中发挥着作用.
研究的目的:
- 研究黑山青少年的氧化还原状态和心血管风险评分 (CVRS) 之间的关系.
- 探索氧化还原稳定参数在改进年轻人心血管疾病风险评估算法的潜力.
主要方法:
- 检查了182名青少年 (16-19岁) 的总抗氧化剂状态 (TAS),超氧化物脱酶 (SOD),先进的氧化蛋白产物 (AOPPs),甲 (MDA) 和总氧化剂状态 (TOS).
- 计算了整体氧化还原平衡的亲氧,抗氧和氧气分数.
- 根据包括肥胖,高血压,失脂症,禁食葡萄糖受损和吸烟在内的因素评估CVRS.
主要成果:
- 在CVRS和TOS,AOPP和MDA之间发现了显著的正相关性.
- 在CVRS和TAS/TOS比率之间观察到负相关性.
- 亲氧和氧分数在较高的CVRS时增加,而抗氧分数在CVRS亚组中没有显著差异.
结论:
- 在青少年中,心血管风险评分和氧化应激标志物之间存在显著的关联.
- 氧化回归稳定参数可能会增强特定年龄的CVD风险算法,超出传统因素.
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