治疗复发性和侵袭性非功能性垂体腺瘤的管理
Nicole A Hefner1, Odelia Cooper2
1Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Journal of clinical medicine
|August 14, 2025
概括
侵袭性非功能性垂体腺瘤 (NFPAs) 构成治疗挑战. 本综述指导专家管理复发性或侵袭性NFPA,探索外科手术,放射治疗和试验性非手术选择.
科学领域:
- 神经内分泌学神经内分泌学
- 在瘤学瘤学.
背景情况:
- 非功能性垂体腺瘤 (NFPAs) 在初始治疗后可能会复发或表现出侵略性.
- 高达47%的残留瘤患者可能会出现复发或进展,需要进一步的干预.
研究的目的:
- 审查当前的证据,以管理反复或激进的NFPAs.
- 为下垂体内分泌学家和神经瘤学家提供关于治疗升级的指导.
主要方法:
- 对攻击性和反复性NFPA研究的文献综述.
- 分析手术,放射治疗和研究医学疗法.
主要成果:
- 重复手术是选择可访问的瘤的一个选择.
- 在75%的NFPA患者中,放射治疗可以控制瘤的生长,但存在风险.
- 几种医疗疗法正在调查中,目前没有获得批准.
结论:
- 对侵袭性/复发性NFPA的治疗决定需要仔细考虑风险和益处.
- 对新型医疗疗法的进一步研究对于改善患者治疗结果至关重要.
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