从透析机传感器测量血红蛋白和血红素的验证与实验室分析相比
Niccolò Morisi1,2, Marco Ferrarini1, Laura Veronesi1,2
1Surgical, Medical, Dental and Morphological Sciences Department (CHIMOMO), University of Modena and Reggio Emilia, 41124 Modena, Italy.
Journal of clinical medicine
|August 14, 2025
概括
在血液透析期间,持续监测血红蛋白 (HB) 和血红素 (HCT) 非常重要. 弗雷斯尼斯5008传感器低估了HB和HCT,但固定的校正因子提高了实时患者监测的准确性.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 生物医学工程 生物医学工程
- 医疗器械技术 医疗器械技术
背景情况:
- 持续监测血红蛋白 (HB) 和血红素 (HCT) 可以提高流体管理和血液透析期间的患者安全.
- 弗雷斯尼斯5008透析机用于估计HB和HCT的超声波传感器,但其临床准确性需要与标准实验室方法进行验证.
研究的目的:
- 评估从Fresenius 5008超声波传感器和传统实验室测量中获得的HB和HCT值之间的一致性.
- 为了评估传感器衍生的HB和HCT在治疗开始时接受血过的患者的准确性.
主要方法:
- 一项探索性观察性研究,涉及20名接受血液过的患者.
- 收集和分析177个配对的血液样本,比较传感器衍生和实验室衍生的HB和HCT值.
- 统计分析包括相关性,回归和布兰德-阿尔特曼图表来评估共识和偏见.
主要成果:
- 与实验室测量相比,来自传感器的HB和HCT值被显著低估 (HB:9.61比11.31g/dL;HCT:27%比34%).
- 在传感器和实验室数据之间观察到强烈的相关性 (HB:r = 0.788;HCT:r = 0.876),表明比例偏差.
- 应用固定校正系数 (+1.69 g/dL HB, +7.55% HCT) 消除了统计差异,并改善了一致性,正如Bland-Altman分析所证实的那样.
结论:
- 弗雷斯尼乌斯5008传感器与实验室HB和HCT有很强的相关性,但在治疗开始时系统地低估了值,可能是由于血液稀释.
- 实施固定校正因子可以提高传感器衍生的HB和HCT测量的准确性.
- 经过校正的传感器数据有可能在血液透析期间进行可靠的实时监测,从而改善患者管理.
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