线还是设备? 对LAA闭塞患者闭塞策略的现实世界分析
Saif Zako1, Kathrin Klein1, Asena Öz1
1Department of Cardiology, Pulmonology and Vascular Medicine, University Hospital Düsseldorf, Medical Faculty of the Heinrich Heine University Düsseldorf, 40225 Düsseldorf, Germany.
Journal of clinical medicine
|August 14, 2025
概括
在左心房附属物阻塞 (LAAO) 程序后,Z和ProGlideTM设备在血管闭塞方面表现出类似的安全性和有效性. 对于高风险患者来说,Z可能是一个更简单,更具成本效益的选择.
科学领域:
- 心脏病学 心脏病学
- 干预心脏病学 干预心脏病学
- 血管外科 血管外科
背景情况:
- 左心房尾阻塞 (LAAO) 为高出血风险的心房动 (AF) 患者提供抗凝药的替代方案.
- 在大孔静脉接入后有效的血管闭塞至关重要,但具有挑战性,特别是在患有并发症的患者中.
- 这项研究评估了两个关闭技术:Z和ProGlideTM装置.
研究的目的:
- 为了比较Z的安全性和有效性与LAAO后静脉关闭的ProGlideTM装置.
- 作为主要终点,评估临床相关的出血率 (BARC ≥2).
- 评估二次终点,包括30天死亡率和住院时间.
主要方法:
- 一个单一中心的观察性研究包括了163名在2021年至2024年期间接受LAAO的患者.
- 根据操作者的偏好,使用Z (n=126) 或ProGlideTM (n=37) 进行了静脉关闭.
- 分析了患者数据,以检查出血事件,死亡率和住院时间.
主要成果:
- Z-接组包括更多伴随疾病的老年患者.
- 临床相关的出血率是可比的:12.6%的Z和13.5%的ProGlideTM.
- 在这两组中都没有观察到30天死亡率,住院时间长度相似.
结论:
- 两种Z-suture和ProGlideTM技术在LAAO后静脉关闭的安全性和有效性都相当.
- 在高风险患者群体中,Z是一种潜在的更简单,更具成本效益的常规护理替代方案.
- 这些发现支持在LAAO程序的临床实践中考虑Z.
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