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Updated: Sep 11, 2025

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在患者的性别差异和长期结果与左捆支部区域节奏与右心室节奏相比,左捆支部区域节奏

Po-Wei Yang¹, Uei Chen¹, Po-Jui Wu¹

¹Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, 123, Dapi Road, Niao-Sung District, Kaohsiung City 833, Taiwan.

Journal of clinical medicine

|August 14, 2025

概括

与右心室节拍 (RVP) 相比,左捆支部区域节拍 (LBBAP) 显著减少了诸如心力衰竭住院和死亡率之类的不良结果. 对于男性患者来说,LBBAP具有特别的益处,并且减少了女性心力衰竭住院的情况.

科学领域:

心脏病学心脏病学
电子生理学电子生理学
医疗器械技术医疗器械技术

背景情况:

长期的右心室节奏 (RVP) 可能导致电气和机械失调,导致患者不良后果.
左捆支部区域节奏 (LBBAP) 提供了一个更生理的替代方案,但其长期的比较结果,特别是关于性别差异,尚未得到充分证实.

研究的目的:

为了比较LBBAP与RVP的长期临床结果,在接受de novo心脏起器植入的患者中.
与RVP相比,调查LBBAP疗效中的潜在性别差异.

主要方法:

一项从2017年1月到2024年7月的队列研究,涉及1211名患者 (RVP: n=789,LBBAP: n=422).
倾向分数匹配 (PSM) 用于创建可比的组进行分析.
主要结局是所有原因死亡率,心力衰竭住院 (HFH) 和节奏诱导心肌病 (PICM) 的综合结果.

主要成果:

在PSM (764名患者) 后,与RVP相比,LBBAP与主要结局 (8.6%与24.6%),高血压高血压高血压高血压高血压高血压高血压高血压高血压高血压高血压高血压高血压高血压高血压高血压高血压高血压高血压高血压高血压高血压高血压高血压高血压高血压高血压高血压高血压高血压高血压高血压高血压高血压高血压高血压高血压高血压高血压高血压高血压高血压高血压高血压高血压高血压高血压高血压高血压高血压高血压高血压高血压高血压高血压高血压高血压高血压高血压高血压高血压高血压高血压高血压高血压高血压低血压高血压高血压高血压高血压高血压高血压高血压高血压高血压高血压高血压高血压高血压高血压高血压高血压高.
在RVP或LBBAP组内,在结果中没有观察到任何显著的性别差异.
在2年的随访期间,男性LBBAP患者显示所有终点的发病率低于RVP男性. 与RVP女性相比,女性LBBAP患者的HFH发病率明显较低 (HR0.14).

结论:

与RVP相比,LBBAP显示了不良临床结果的风险降低,包括HFH和死亡率,无论患者的性别如何.
与RVP相比,LBBAP在主要终点中为男性患者提供了显著的好处,并特别降低了女性患者的HFH风险.
需要进一步的研究来阐明特定的基于性别的对LBBAP的反应.

关键词:

临床结果的临床结果.心力衰竭住院治疗住院治疗左捆分支机构地区节奏节奏.死亡率死亡率在性爱中,性爱是性爱.

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