在患有伪偏偏甲状腺症的患者中,过敏的自然史
Jaclyn Tamaroff1, Ashley H Shoemaker1
1Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37212, USA.
Journal of clinical medicine
|August 14, 2025
概括
患有1A和1B类型的伪偏偏甲状腺症 (PHP) 的患者可能会出现早期发作的过,但随着时间的推移,症状会稳定下来. 早期诊断有助于通过结构化的饮食和部分控制来管理肥胖风险.
科学领域:
- 内分泌学 在内分泌学.
- 遗传学 是一个遗传学.
- 儿科 儿科 儿科
背景情况:
- 伪低甲状腺症 (PHP) 包含由激素抵抗,肥胖和发育迟缓所标志的遗传疾病.
- 该GNAS基因的印记影响饮食行为,可能在母 (PHP1A,PHP1B) 和父 (PPHP) 遗传之间存在差异.
研究的目的:
- 为了探索和比较PHP1A,PPHP和PHP1B患者队列中的饮食行为.
- 为了确定与PHP亚型相关的过和养模式的潜在差异.
主要方法:
- 使用护理人员报告的问卷 (吞,饮食行为,养) 和自我报告的饮食行为问卷.
- 包括58名PHP1A,13名PPHP,10名PHP1B患者和124名肥胖儿科对照.
主要成果:
- 与PPHP患者相比,PHP1A患者的肥胖风险更高 (BMI 39.8 与 30.2 公斤/米2).
- 与对照组 (5,2岁) 相比,PHP1A (2.0岁) 和PHP1B (1.1岁) 报告的食物兴趣更早出现.
- 过,和食行为与对照人群相似;过在青春期之前达到顶峰,在纵向上保持稳定.
结论:
- 在PHP1A/1B患者中,可能出现早期发病的过,但随着年龄的增长而没有进展.
- 虽然吃得过多可能发生,但破坏性寻找食物的行为并不常见.
- 早期诊断有助于在PHP1A/1B中通过计划的饮食和控制的部分来积极管理肥胖风险.
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