肝移植治疗癌症目前的挑战和新兴解决方案
Steven M Elzein1, Elizabeth W Brombosz1, Sudha Kodali2,3,4
1Department of Surgery, Houston Methodist Hospital, 6550 Fannin Street Suite 1661, Houston, TX 77030, USA.
Journal of clinical medicine
|August 14, 2025
概括
肝移植 (LT) 越来越多地用于肝癌,提供更好的生存率. 扩大供体选择和获取范围,为原发性和二次性肝癌患者带来了更大的希望.
科学领域:
- 肝病学和移植瘤学 肝病学和移植瘤学
背景情况:
- 肝移植 (LT) 是一种日益增长的肝脏恶性瘤治疗方法,与其他疗法相比,其生存率更高.
- 在瘤学中,LT的适用范围已经扩大到肝细胞癌等原发性肝癌之外,包括肝内胆管癌和转移性疾病.
研究的目的:
- 审查肝移植在治疗初级和二级肝癌中的作用和适用性.
- 讨论捐赠者池扩张的进展以及不同患者群体获得LT的机会.
主要方法:
- 审查目前的文学和临床实践在移植瘤学.
- 对患有肝脏恶性瘤的患者中LT发展的指示和结局的分析.
主要成果:
- 对于各种原发性和二次性肝癌,包括肝细胞癌,胆管癌和转移,LT提供了更高的生存率.
- 新的新辅助疗法已经扩大了移植可接受的疾病负担.
- 像活体捐赠者,扩展标准捐赠者和机器输液这样的创新正在扩大捐赠者池.
结论:
- 肝移植是肝脏恶性瘤的重要和不断扩大的治疗方式,提供长期存活.
- 在捐赠者策略和公平获取方面的持续进步对于最大限度地发挥LT在瘤学中的好处至关重要.
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