雷米马佐拉姆和普罗波福在脊柱手术期间对手术内运动唤起潜力的影响:一个随机交叉试验
Bo Rim Kim1, Hye-Bin Kim2, Moo Soo Kim2
1Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea.
Journal of clinical medicine
|August 14, 2025
概括
在全静脉麻醉 (TIVA) 中使用的雷米马佐拉姆对运动唤起潜力 (MEP) 产生了与普罗波相似或优于的效果. 这表明remimazolam是脊柱手术期间MEP监测的可行替代品.
科学领域:
- 麻醉学 麻醉学
- 神经生理学 神经生理学
背景情况:
- 静脉内全麻醉 (TIVA) 通常使用普罗波和雷米芬坦尼尔.
- 普罗波部分降低了运动唤起潜能 (MEP) 的幅度,而雷米芬坦尼尔的影响很小.
- 尽管在TIVA中使用了remimazolam,但对其对MEP的影响的数据有限.
研究的目的:
- 为了比较普罗波福与雷米马佐拉姆在与雷米芬坦尼尔结合时对MEP幅度和延迟的影响.
- 评估在TIVA期间的MEP监测中,雷米马佐拉姆作为对普罗波的潜在替代品.
主要方法:
- 一项交叉设计研究,涉及18名接受脊柱手术的患者.
- 患者接受了propofol或remimazolam,然后切换到另一种药物.
- 主要结果包括MEP振幅和延迟测量.
主要成果:
- 与雷米马佐拉姆相比,普罗波在MEP振幅中引起了更大的抑郁 (p=0.047).
- 欧洲议会议员的延迟时间显示,普罗波福和雷米马佐拉姆之间没有显著差异 (p=0.070).
- 一名患者在雷米马佐拉姆治疗下经历了严重的运动,这表明在没有神经肌肉阻塞的情况下减少了秋的可能性.
结论:
- 雷米马佐拉姆在脊柱手术中表现出类似或更高的MEP幅度和延迟效应与普罗波福.
- 雷米马佐拉姆在TIVA的MEP监测中显示出作为普罗波福尔替代品的希望.
- 可能需要进一步的研究来评估在特定的手术背景下对雷米马佐拉姆的秋和最佳剂量.
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