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化学伤害后视网膜神经纤维和节细胞层的变化:一项前性研究

Justina Skruodyte^1,2, Justina Olechnovic², Pranas Serpytis³

¹Faculty of Medicine, Vilnius University, LT-01131 Vilnius, Lithuania.

Journal of clinical medicine

|August 14, 2025

概括

严重的化学眼烧伤会影响视力,但整体视网膜神经纤维层 (RNFL) 厚度保持稳定. 然而,严重的烧伤 (Dua等级≥3) 显著稀释鼻腔RNFL,表明烧伤严重程度预测视力变化.

科学领域:

眼科医生眼科眼科
眼睛的创伤眼睛的创伤
视网膜成像视网膜成像

背景情况:

化学眼睛烧伤是眼科紧急情况,有可能导致永久的视力丧失.
在化学烧伤后评估后部段结构变化对于理解长期影响至关重要.
以前的研究还没有完全阐明化学烧伤对视网膜层的影响.

研究的目的:

为了评估后部部分的结构变化,特别是视网膜神经纤维层 (RNFL) 和质细胞复合体 (GCL++) 厚度,在化学眼烧伤后.
为了确定烧伤严重程度 (Dua等级) 和后部段结构变化之间的相关性.
为了确定化学眼烧伤患者RNFL稀释的预测因素.

主要方法:

光学连贯断层扫描 (OCT) 用于测量54名化学烧伤患者的64只眼睛和87只健康的对照眼睛的RNFL和GCL++厚度.
在急性阶段和3个月和6个月的随访期间进行了测量.
用物流回归分析来确定RNFL稀释的预测因素,Dua等级是关键因素.

主要成果:

在化学烧伤患者和对照人群之间,没有发现总体RNFL或GCL++厚度的显著差异.
严重的化学烧伤 (Dua等级≥3) 与显著的RNFL稀释有关,特别是在鼻子象限 (调整后p=0.035).
更高的Dua等级被确定为RNFL稀释的独立预测因素 (OR:4.816,p = 0.037).

结论:

虽然整体RNFL和GCL++厚度没有显著影响,但严重的化学烧伤导致鼻子象限局部RNFL稀释.
烧伤严重程度,如Dua等级所示,是RNFL稀释的重要预测因素.
需要进一步的纵向研究,使用更大的队列来证实这些发现,并探索长期的视觉结果.

关键词:

化学眼睛烧伤化学眼睛烧伤化学伤害是因为化学伤害.视网膜的状细胞细胞.视网膜神经纤维层是一种神经纤维层.视网膜的结构变化

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