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埃里奥博特里亚日本菌 (Thunb.) 的影响林德尔. 林德尔. 林德尔. 林德尔. 林德尔. 林德尔. 林德尔. 林德尔. 林德尔. 斑马鱼胚胎发生,行为和生化途径的叶子提取物

Jorge Barros^1,2, Irene Gouvinhas¹, Carlos Venâncio¹

¹Centre for Research and Technology of Agro-Environmental and Biological Sciences (CITAB, Inov4Agro), University of Trás-os-Montes and Alto Douro (UTAD), Quinta de Prados, 5000-801 Vila Real, Portugal.

Molecules (Basel, Switzerland)

|August 14, 2025

概括

乙醇Eriobotrya japonica叶片提取物在斑马鱼胚胎中显示出度依赖的发育和行为效应,激活抗氧化防御而不会引起氧化损伤.

科学领域:

环境毒理学环境毒理学
植物化学植物化学
发育生物学是发展生物学.

背景情况:

叶片提取物 Eriobotrya japonica 叶片提取物含有多.
关于其对水生有毒性的数据有限.
斑马鱼胚胎是发展毒性评估的模型.

研究的目的:

评估E. japonica叶片提取物对斑马鱼胚胎的毒理影响.
评估形态,行为和生化影响.
在水生模型中确定提取物的安全概况.

主要方法:

根据经合组织的指导方针确定了96小时的LC50.
斑马鱼胚胎暴露在75和150毫克/升的提取物中90小时.
评估了形态,行为和生化参数 (SOD,CAT,ROS,ACHE).

主要成果:

LC50>150毫克/升,表明毒性低.
显著的发育影响 (生存,化,游泳膀,黄囊) 在150mg/L.
增加了SOD和CAT活动,减少了ACHE活动,但没有显著的ROS增加.
观察到与发育效应相关的行为障碍.

结论:

E. japonica 叶片提取物在斑马鱼胚胎中表现出度依赖的发育和行为毒性.
提取物激活抗氧化防御 (SOD,CAT) 并抑制ACHE.
结果表明潜在的生物活性和双重效应,需要进一步的安全性和治疗研究.

关键词:

丹尼奥·雷里奥 (Danio Rerio) 是一个日本鱼 (Eriobotrya japonica) 是一种日本鱼.行为行为行为行为.生物化学途径的发生.胚胎发生是胚胎发生.

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