中国菜中的乳酸细菌:其隔离和体外益生菌性质
Ming-Yang Han1, Wen-Yong Lou2, Meng-Fan Li1
1Food Science School, Guangdong Pharmaceutical University, Zhongshan 528458, China.
Foods (Basel, Switzerland)
|August 14, 2025
概括
研究人员选了254种乳酸细菌 (LAB) 菌株,从酸菜中选了益生菌的潜力. 乳植物菌植物菌F42由于其核酸降解活性,显示出有前途的尿酸降低能力.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 营养科学 营养科学
背景情况:
- 超尿血症的管理是一个日益严重的健康问题.
- 益生菌为高尿血症提供了潜在的治疗途径.
- 有效的隔离和鉴定益生菌菌株对于应用至关重要.
研究的目的:
- 从中国酸菜中分离和选乳酸细菌 (LAB),以检测其益生菌性质.
- 评估LAB菌株的核酸降解活性,作为尿酸降低潜力的标志物.
- 为了确定一个有前途的益生菌候选人管理hyperuricemia.
主要方法:
- 从中国酸菜中分离和选254个LAB菌株.
- 孤立菌株的基因组和表型特征.
- 评估胆汁盐耐受性,Caco-2细胞粘附性,核酸降解和抗李斯特菌活性.
- 根据功能特征来选择F42植物菌.
主要成果:
- 乳植物菌植物植物F42表现出高胆汁盐耐受性 (19.46 ± 4.33%).
- F42对Caco-2细胞具有很强的粘附性 (1.89 ± 0.12%) 和有效的核酸降解 (伊诺辛:5.46 ± 0.67 mg∙L−1∙min−1;瓜诺辛:3.84 ± 0.11 mg∙L−1∙min−1).
- 该菌株还显示出显著的抗李斯特菌活性 (抑制区:6.9±0.3毫米).
结论:
- 乳酸植物菌植物菌F42是一种有前途的益生菌候选人,用于治疗高尿血症.
- 实验室内核oside降解活性是选择抗高尿素血症益生菌的有价值指标.
- 这项研究提供了一种针对高尿血症的益生菌选择的新方法.
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