定义耐治疗双极性抑郁症:ISBD工作组的建议
Eduard Vieta1,2,3,4, Roger S McIntyre5, Trisha Suppes6
1Bipolar and Depressive Disorders Unit, Hospital Clinic de Barcelona, Barcelona, Spain.
Bipolar disorders
|August 14, 2025
概括
建立了对抗治疗双极性抑郁症 (TRBD) 的共识定义,将其确定为对至少两种充足的药理疗法缺乏反应. 这种标准化的定义旨在改善双相情感障碍的临床试验和研究.
科学领域:
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
- 临床研究 临床研究
背景情况:
- 显著一部分双相情感障碍患者经历了耐治疗双相情感抑郁症 (TRBD).
- 缺乏普遍接受的定义阻碍了TRBD的研究和治疗开发.
- 国际双极障碍学会 (ISBD) 召集了一个工作组来解决这个问题.
研究的目的:
- 建立治疗耐药双极性抑郁症 (TRBD) 的标准化定义.
- 促进TRBD临床试验和研究的一致性.
- 引导治疗策略,并为TRBD的监管途径提供信息.
主要方法:
- 进行了全面的文献审查.
- 对现有临床试验数据进行了分析.
- 专家共识会议举行,以制定定义.
主要成果:
- TRBD被定义为在至少两次经批准,适当剂量和坚持药理治疗后,未能达到显著和持续的临床反应.
- 概述了双极性I (BD-I) 和双极性II (BD-II) 抑郁症的特定批准治疗方法和持续时间.
- 对于BD-I,治疗包括奎蒂亚平,卢拉西,奥兰扎平/西,卡里普拉辛和卢马特佩龙.
- 对于BD-II,治疗包括奎蒂亚平和卢马特佩龙.
结论:
- 建立的共识定义为临床试验和研究的一致性提供了清晰度.
- 这一定义是解决TRBD未满足需求的基本步骤.
- 未来的努力将集中在完善定义以实现现实世界的临床应用,并优化患者护理.
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