相关实验视频

Updated: Sep 11, 2025

Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling

Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling

Published on: July 26, 2017

通过非编码RNA及其片段激活收费类受体 (综述)

Ruth Ruiz Esparza-Garrido¹, Miguel Ángel Velázquez-Flores¹

¹Non‑coding RNAs Laboratory, Medical Research Unit in Human Genetics, Children's Hospital 'Dr. Silvestre Frenk Freund', National Medical Center XXI Century, Mexican Institute of Social Security, Mexico City 06720, Mexico.

Molecular medicine reports

|August 14, 2025

概括

非编码RNA (ncRNA) 和它们的片段激活托尔类受体 (TLR),影响免疫反应和细胞过程. 了解这些相互作用为开发新型免疫疗法和治疗各种疾病的治疗点提供了潜力.

科学领域:

分子生物学分子生物学
免疫学免疫学免疫学
遗传学是一个遗传学.

背景情况:

非编码RNAs (ncRNAs) 是基因表达和细胞功能的关键调节者.
ncRNA及其碎片越来越多地被认可为它们在免疫系统激活中的作用.
收费类受体 (TLR) 是关键的模式识别受体,参与先天性和适应性免疫.

研究的目的:

审查通过非编码RNA (ncRNA) 及其碎片激活托尔类受体 (TLR) 的证据.
突出这些相互作用在各种疾病中的参与.
探索ncRNA-TLR相互作用的治疗潜力,用于开发新型免疫疗法.

主要方法:

对ncRNA-TLR相互作用现有证据的文献综述.
对ncRNAs激活TLRs的机制的分析.
检查ncRNA-TLR通路在疾病发病过程中的作用.

主要成果:

ncRNA及其碎片作为TLRs的连接体,调节免疫反应.
这些相互作用与病毒感染,自身免疫性疾病,癌症和神经系统疾病如缺血有关.
对ncRNA-TLR通路的调节失调有助于疾病的发展.

结论:

ncRNA-TLR相互作用是免疫反应和疾病的关键调解者.
TLRs代表了有前途的治疗点,ncRNAs作为潜在的激动剂或对抗剂.
对ncRNA-TLR通路的进一步研究可以导致开发有效的免疫疗法.

关键词:

它们是Aptamers.连接器连接器连接器非编码RNA片段的非编码RNA片段没有编码的RNAs.类似于收费的接收器.

更多相关视频

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR

Published on: March 1, 2019

Using RNA-interference to Investigate the Innate Immune Response in Mouse Macrophages

Using RNA-interference to Investigate the Innate Immune Response in Mouse Macrophages

Published on: November 3, 2014

相关概念视频

Types of RNA

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...

RNA Interference

RNA Interference

RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...

Experimental RNAi

Experimental RNAi

RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...

Signal Transduction: Overview

Signal Transduction: Overview

Cells respond to many types of information, often through receptor proteins positioned on the membrane. They respond to chemical signals, such as hormones, neurotransmitters, and other signaling molecules, initiating a series of molecular reactions to produce an appropriate response. This is called signal transduction. Cells also coordinate different responses elicited by the same signaling molecule via mediators, allowing molecular cross-talk.
Typically, signal transduction involves three...

siRNA - Small Interfering RNAs

siRNA - Small Interfering RNAs

Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...