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在T4或N3鼻癌中风险分层

Lin-Feng Guo¹, Lu-Chao Zhu¹, Yi-Feng Yu¹

¹Department of Radiation Oncology, Xiamen Cancer Center, Xiamen Key Laboratory of Radiation Oncology, the First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.

Cancer research and treatment

|August 14, 2025

概括

第九版AJCC/UICC分期系统显示了第三阶段鼻癌 (NPC) 的预后差异. T4N3 NPC患者的生存结果较差,应该作为一个不同的群体来对待.

科学领域:

在瘤学瘤学.
癌症的分期癌症的分期
头部和部癌症头部和部癌症

背景情况:

鼻癌 (NPC) 的分期对于治疗计划和预后至关重要.
美国癌症联合委员会 (AJCC) /国际癌症控制联盟 (UICC) 阶段系统的第九版为NPC分类提供了一个框架.
了解第三阶段NPC中的预后异质性对于优化患者护理至关重要.

研究的目的:

用第九版AJCC/UICC分期系统评估第三阶段NPC患者的预后变异.
在第三阶段NPC中确定不同的子组,这些子组可能受益于定制的治疗策略.
评估不同T和N组合在NPCIII阶段的临床意义.

主要方法:

在2015年1月至2021年12月期间诊断的309名III期NPC患者的回顾性分析.
基于第九版AJCC/UICC分级系统 (T1-3N3或T4N0-3) 的分类.
使用了卡普兰-梅尔生存分析和多变量考克斯回归.

主要成果:

与T1-3N3和T4N0-2组相比,患有T4N3疾病的患者远程无转移存活率 (DMFS),无进展存活率 (PFS) 和整体存活率 (OS) 显著降低.
局部无复发生存率 (LRFS) 在T4N3和其他III期子组之间是可比的.
T4N3患者的5年DMFS为44.7%,PFS为27.6%,OS为45.9%,明显低于其他III期组.

结论:

第九版AJCC/UICC分期系统揭示了第三阶段NPC中的预后异质性.
在T4N3小组中,生存结果明显较差.
无论分期版本,T4N3 NPC应被认为是针对量身定制的治疗方法的独特临床实体.

关键词:

鼻癌是指鼻癌.预测异质性的预测.风险分层是指风险的分层.阶段化系统分阶段化系统.幸存的生存方式

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