在Oropouche病毒感染的神经表现:一个系统的审查和元分析
Ranjit Sah1, Prakasini Satapathy2, Abhay M Gaidhane3
1BMC South, Boston Medical Center Health System, Boston, Massachusetts, USA.
Journal of medical virology
|August 14, 2025
概括
耳鼻病毒 (OROV) 感染经常导致神经症状,如头痛和肌肉疼痛. 本次审查强调了需要更好地诊断和监测OROV神经并发症的需要.
科学领域:
- 亚博病毒学 亚博病毒学
- 神经学 神经学
- 公共卫生 公共卫生
背景情况:
- 耳鼻病毒 (OROV) 是一种新兴的树冠病毒,在热带/亚热带地区普遍存在.
- 虽然OROV通常会导致发烧性疾病,但神经系统并发症越来越多,但研究不足.
- 了解神经症状的患病率对于公共卫生管理至关重要.
研究的目的:
- 系统地审查和元分析奥罗普什病毒感染中神经学表现的流行情况.
- 为了识别与OROV相关的常见神经症状.
- 为OROV相关的神经综合征的诊断和监测策略提供信息.
主要方法:
- 在PubMed,Web of Science和Embase中按照PRISMA 2020指南进行系统的文献搜索.
- 使用嵌套知识软件和修改后的纽卡斯尔-太华尺度进行数据提取和质量评估.
- 使用R软件对聚合流行率的元分析,对异质性和出版偏差进行了评估.
主要成果:
- 包括来自巴西,秘鲁和哥伦比亚的10项研究,涉及2872名患者.
- 神经症状的高综合患病率:头痛 (89.16%),肌痛 (70.71%) 和眼睛疼痛 (52.87%).
- 观察到显著的异质性,需要进一步研究地理和诊断变异.
结论:
- 神经症状在OROV感染中很常见,头痛,肌痛和眼睛疼痛是最常见的.
- 与其他树冠病毒的临床重叠使诊断复杂化,强调需要改进诊断工具.
- 在特有和新兴地区加强对树状病毒神经综合征的监测至关重要.
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