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关于通过离子流动性光谱测量来传达PFAS识别信心的最新指南

Anna K Boatman¹, Jessie R Chappel^2,3,4, Kaylie I Kirkwood-Donelson⁵

¹Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27514, United States.

Environmental science & technology

|August 14, 2025

概括

研究人员建议使用高分辨率质谱仪 (HRMS) 识别每和多基基物质 (PFAS) 的统一可信度水平. 本指南旨在在环境和人体样本中关于PFAS污染的统一报告.

科学领域:

环境化学环境化学
分析化学分析化学
毒理学毒理学毒理学

背景情况:

全球的per-和多醇基物质 (PFAS) 污染很普遍,在消费品,血液和饮用水等多种矩阵中检测到.
非目标分析 (NTA) 越来越多地用于在环境和生物样本中识别PFAS,需要标准化的报告方法.
通过高分辨率质谱测量 (HRMS) 识别小分子的现有信心水平需要统一和改进PFAS分析的指导.

研究的目的:

调查目前报告PFAS使用LC,GC和/或IMS与HRMS结合识别的可信度水平的做法.
建议为PFAS识别提供统一,简单的信任级指南.
将PFAS特有的属性和离子运动谱 (IMS) 碰撞截面 (CCS) 值纳入拟议的指南.

主要方法:

审查科学文献中关于PFAS可信度水平报告的当前做法.
为PFAS识别制定统一的信任水平框架.
整合PFAS特有的化学特性和IMS衍生的碰撞横截面 (CCS) 数据.

主要成果:

在目前的PFAS信任级报告实践中发现了不一致性.
提出了一个统一的信任级指导系统,用于PFAS的识别.
证明了将IMS CCS值纳入IMS CCS值的实用性,以提高对PFAS识别的信心.

结论:

统一的信任级别系统对于HRMS识别的PFAS的一致和客观报告至关重要.
拟议的指南包括PFAS属性和IMS CCS,为研究人员提供了一种标准化的方法.
改进的报告将提高我们对PFAS污染及其影响的理解.

关键词:

高分辨率质谱仪 (HRMS) 是一种高分辨率质谱仪.识别信任识别的信心离子移动性谱仪 (IMS) 是一种离子移动性谱仪.非目标分析 (NTA)通过和多基基物质 (PFAS)

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