研究结核病治疗的肺内药理动力学:对方法的系统性审查
Isabella van der Feltz1, Haini Wen2, Rob E Aarnoutse1
1Department of Pharmacy, Pharmacology and Toxicology, Radboud University Medical Center, Nijmegen, The Netherlands.
The Journal of antimicrobial chemotherapy
|August 14, 2025
概括
了解肺内药物度对于优化结核病治疗至关重要. 本综述确定和评估了采样,量化和建模肺部抗结核病药物药理动学的各种方法.
科学领域:
- 药理学 药理学是指药理学的学科.
- 结核病研究 结核病研究
- 药物运输 药物运输 药物运输
背景情况:
- 在病变部位上适当的抗结核病 (TB) 药物度对于病变灭菌至关重要.
- 关于肺内药物度的数据有限,这阻碍了结核病治疗的优化.
研究的目的:
- 系统地审查取样,量化,描述和预测人类抗结核药物的肺内药理学方法.
主要方法:
- 在Embase和PubMed进行系统的文献搜索 (最后一次搜索于2024年7月18日).
- 分类253项确定研究对采样技术,定量分析和建模方法进行了分类.
- 包括所有类型的肺部疾病的研究.
主要成果:
- 常见的采样方法包括支气管支气管洗 (115项研究) 和组织活检 (51项研究).
- 液体染色学-并联质谱学 (LC-MS/MS) 是主要的量化方法 (67项研究).
- 用于数据预测,使用了群体药动力学建模 (32项研究) 和基于生理学的药动力学建模 (35项研究).
结论:
- 已识别的方法具有诸如侵入性,复杂性,成本和缺乏标准化的局限性.
- 选择的方法必须准确地反映疾病部位的药理动力学.
- 仔细考虑方法特定因素对于研究肺内药理学至关重要.
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