增强的NIR-II纳米粒子探头用于PSMA向的分子成像和前列腺癌诊断
Zhongji Jiang1,2, Jin Zhang3, Jiali Jin3
1Department of Biology, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong, 518055, People's Republic of China.
International journal of nanomedicine
|August 14, 2025
概括
研究人员开发了一种新的近红外II (NIR-II) 光纳米探针用于前列腺癌 (PCa) 成像. 这种针对PSMA的探头可以深入组织,具有高特异性,可以改善手术指导和诊断.
科学领域:
- 生物医学工程 生物医学工程
- 光学成像技术的成像
- 纳米技术 纳米技术
背景情况:
- 前列腺特异性膜抗原 (PSMA) 是前列腺癌 (PCa) 的关键生物标志物.
- 目前的PSMA向成像剂面临着诸如辐射暴露和不良的手术内性能等局限性.
- 需要先进的成像探测器,提高了PCa检测的特异性和透性.
研究的目的:
- 开发一种新的近红外II (NIR-II) 光纳米探针,用于增强PCa的体内和体外成像.
- 为了评估探针的准特异性,瘤积累和生物相容性.
- 评估探针在光导向手术和ex vivo瘤评估方面的潜力.
主要方法:
- 有机半导体聚合物 (OSP12) 自组装成纳米粒子 (NP).
- 结合OSP12 NP与ACUPA-SH,一个针对PSMA的小部分,以创建PSMA-OSP12 NP.
- 在PSMA阳性/阴性细胞系和PCa异种移植小鼠模型中的体外和体内评估,以及生物安全性评估.
主要成果:
- PSMA-OSP12 NPs表现出强大的NIR-II光,高光稳定性和深层组织透.
- 在体内成像显示选择性瘤积累,48小时后瘤与背景比率 (TBR) 的峰值为7.40±1.28.
- 与现有药物相比,探针表现出更高的性能,没有显著的系统毒性.
结论:
- PSMA-OSP12 NPs代表了一个有前途的NIR-II光探针用于PCa成像.
- 该探针提供了出色的瘤特异性,深层组织成像能力和良好的生物相容性.
- 这些发现支持PSMA-OSP12NP在光导向手术和ex vivo瘤评估中的应用.
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