肠道微生物群的饮食指数与心血管--代谢综合征之间的关联:基于人口的研究
Dan Long1, Chenhan Mao2, Haoyu An3
1Department of Gastroenterology, The First Hospital of Hunan University of Chinese Medicine, Changsha, China.
较高的肠道微生物群 (DI-GM) 饮食指数得分与心血管-脏-代谢 (CKM) 综合征的发病率较低有关. 通过饮食模式改善DI-GM可能会降低CKM综合征风险.
科学领域:
- 营养科学 营养科学
- 微生物组研究 微生物组研究
- 公共卫生 公共卫生
背景情况:
- 心血管--代谢 (CKM) 综合征对全球健康构成重大挑战.
- 肠道微生物群的饮食指数 (DI-GM) 量化了饮食质量及其与肠道微生物群多样性的联系.
- 了解DI-GM和CKM综合征之间的关系对于预防和治疗至关重要.
研究的目的:
- 调查DI-GM得分与CKM综合征的患病率之间的关联.
- 通过饮食干预来探索CKM综合征的潜在预防策略.
- 为CKM综合征量身定制的治疗方法提供见解.
主要方法:
- 这是一项采用NHANES (2007-2018) 来自8,400名成年人 (20岁以上) 的数据进行的横截面研究.
- 分析采用了单变量和多变量加权后勤回归模型.
- 限制立方线 (RCS) 和子组分析被用于评估关联和潜在的相互作用.
主要成果:
- 更高的DI-GM得分与较低的CKM综合征患病率显著相关 (OR=0.87,p<0.001).
- RCS分析表明DI-GM得分与CKM综合征风险之间存在线性关系.
- 亚组分析显示,性别有显著的相互作用 (p=0.004),在美国女性中观察到更强的保护作用.
结论:
- DI-GM得分显示,与CKM综合征的风险存在逆相关性.
- 优化饮食模式以增强DI-GM与患CKM综合征的风险降低有关.
- 针对肠道微生物群的饮食干预可能是预防CKM综合征的有希望的方法.
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