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Updated: Sep 11, 2025

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索尼克刺在脊髓损伤中发出信号:机制和治疗影响

Mingjuan Du1, Xiaozhen Ji2, Weiting Chen3

  • 1Department of Emergency, Taizhou Integrated Chinese and Western Medicine Hospital, Taizhou, Zhejiang, China.

Frontiers in molecular neuroscience
|August 14, 2025
PubMed
概括

索尼克 (Shh) 信号通路显示,通过促进神经保护和再生,对脊髓损伤 (SCI) 修复有希望. 然而,将这些发现转化为临床应用仍然存在挑战.

关键词:
的 Gli 转录因子.这是一个SMO SMO.索尼克刺信号通道的信号通道神经元神经元的神经元脊髓损伤导致的脊髓损伤

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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