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Updated: Sep 11, 2025

Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates
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针对瘤相关抗原的工程人类B细胞表现出抗原呈现和抗体介导功能

Alexander Boucher1, Courtney Anderson2, Rochelle Hinman2

  • 1ElevateBio, Waltham, MA, United States.

Frontiers in immunology
|August 14, 2025
PubMed
概括

工程B细胞可以被开发成一种新的癌症治疗方法. 这些修改后的B细胞可以向瘤抗原,激活免疫反应,并消除癌细胞,为固体瘤治疗提供了一个有前途的新方法.

关键词:
B细胞是B细胞的组成部分.抗体是一种抗体.抗原呈现的呈现方式.细胞工程 细胞工程基因组编辑 基因组编辑免疫复合体是一个复杂的免疫系统.第三级淋巴体结构 (TLS)

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