相关实验视频

Updated: Sep 11, 2025

Establishment and Histological Analysis of Esophageal Organoids Modeling the Progression from Normal to Cancerous Tissues

Establishment and Histological Analysis of Esophageal Organoids Modeling the Progression from Normal to Cancerous Tissues

Published on: May 30, 2025

表面食道状细胞癌在不同的透生长模式中的临床病理特征

Xing Qi¹, Zhenxiang Zuo², Bin Yu¹

¹Department of Gastroenterology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.

Frontiers in oncology

|August 14, 2025

概括

表面食道状细胞癌 (SESCC) 的透生长模式 (INF) 与瘤的攻击性有关. 瘤大小,IPCL和透深度预测INFb,而淋巴血管入侵表明INFc,有助于治疗决策.

科学领域:

胃肠病学胃肠病学
在瘤学瘤学.
病理学病理学病理学

背景情况:

表面食道状细胞癌 (SESCC) 涉及仅限于粘膜或粘膜下部的瘤病变.
透生长模式 (INF) 在评估各种癌症的瘤攻击性和预后方面至关重要.
在SESCC中INF的作用需要进一步阐明.

研究的目的:

调查不同INF类型和SESCC中的临床病理特征之间的关联.
在SESCC中识别INF类型的预测因素.
改善SESCC的手术前评估和治疗选择.

主要方法:

对368名SESCC患者进行了内镜下层剖析 (2014-2023) 的回顾性分析.
根据日本食道学会的指导方针,INF被分为INFa,INFb和INFc.
单变量和多变量逻辑回归分析以确定INF类型的显著临床病理预测因素.

主要成果:

INF与瘤大小,总体形态,内皮质乳头毛细管环 (IPCL),透深度,淋巴血管入侵和阳性切除边缘有关.
瘤大小,IPCL和透深度是INFb的独立预测因素.
淋巴血管侵袭是INFc.的独立风险因素.

结论:

INFc型SESCC的特点是瘤尺寸更大,特定的IPCL类型 (B2) 和抑郁的形态.
与INFa和INFb相比,INFc类型的SESCC表现出更深的透,更高的淋巴血管入侵率和正切除边缘.
瘤大小,IPCL和形态的内镜评估有助于预测INF和瘤状况,指导手术和术后管理.

关键词:

在INF INF中.在IPCL中,IPCL是IPCL.这是SESCCCC.临床病理学特征临床病理学特征透深度的透深度是什么

更多相关视频

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids

Published on: December 23, 2022

Author Spotlight: Advancing Early Detection and Treatment of Gastrointestinal Tumors

Author Spotlight: Advancing Early Detection and Treatment of Gastrointestinal Tumors

Published on: February 16, 2024

相关概念视频

Barrett Esophagus-I: Introduction

Barrett Esophagus-I: Introduction

Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...

Tumor Progression

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

Esophageal Strictures-I: Introduction

Esophageal Strictures-I: Introduction

Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...

Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

Cancer Cell Migration through Invadopodia

Cancer Cell Migration through Invadopodia

Invadosome is a broad category of cell surface structures with proteolytic activity that degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However,...

Metastasis

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...