相关实验视频

Updated: Sep 11, 2025

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Published on: September 27, 2024

基于PCAT7的BRCA临床预后模型的探索

Zhi Zhang¹, Chaocheng Xiang², Tong Chen³

¹Department of Hepatobiliary Surgery, Guangxi Medical University Affiliated Wuming Hospital, Nanning, China.

Frontiers in oncology

|August 14, 2025

概括

乳腺癌 (BRCA) 中长非编码RNA PCAT7 的高表达与预后不佳相关. PCAT7作为BRCA的潜在诊断和预后生物标志物,影响免疫细胞透.

科学领域:

在瘤学瘤学.
基因组学就是基因组学.
分子生物学分子生物学

背景情况:

乳腺癌 (BRCA) 是女性中最常见的癌症.
长非编码RNA前列腺癌相关转录7 (PCAT7) 的过度表达与不良的BRCA预后有关.

研究的目的:

研究PCAT7在乳腺癌中的功能和预后意义.
评估PCAT7作为BRCA的潜在诊断和预后生物标志物.

主要方法:

利用TCGA BRCA数据进行预后潜力的评估.
收集BRCA亚型的临床样本,用于PCAT7表达的验证.
采用WGCNA来识别PCAT7共同表达的基因模块和用于途径分布的丰富分析.
建立了一个基于PCAT7的临床指标评分模型,并分析了与免疫标记物的相关性.

主要成果:

在BRCA中,PCAT7表达显著升高,与患者预后不佳相关.
在各种BRCA亚型中,PCAT7显示出诊断潜力.
与PCAT7相关的基因模块在免疫和与癌症相关的途径中得到了丰富.
PCAT7表达与免疫检查点基因,三级淋巴体结构和抑制免疫细胞透相关.

结论:

来自PCAT7的临床评分与BRCA患者的预后有显著的关联.
PCAT7被确定为乳腺癌预后和免疫反应的有价值生物标志物.

关键词:

这就是BRCA BRCA.在PCAT7中使用PCAT7.临床模型PCAT7临床模型在WGCNA中,WGCNA是WGCNA.免疫细胞免疫细胞

更多相关视频

gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair

gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair

Published on: October 6, 2014

Functional Assessment of BRCA1 variants using CRISPR-Mediated Base Editors

Functional Assessment of BRCA1 variants using CRISPR-Mediated Base Editors

Published on: February 28, 2021

相关概念视频

Cancer Survival Analysis

Cancer Survival Analysis

Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...