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在先天性心脏病中神经发育障碍与循环代谢物和肠道微生物群组成变化之间的关联

Jia An¹, Qiang Wang², Zihao Bai¹

¹Nanjing Children's Hospital, Clinical Teaching Hospital of Medical School, Nanjing University, Nanjing, China.

Frontiers in microbiology

|August 14, 2025

概括

患有先天性心脏病的儿童的神经发育障碍与肠道细菌和血清代谢物有关. 烯酸和Escherichia属显示显著的关联,提供潜在的治疗点.

科学领域:

在儿科神经发育的多omics研究.
在先天性心脏病中研究肠-大脑轴.

背景情况:

神经发育障碍 (ND) 显著影响先天性心脏病 (CHD) 患者的生活质量.
了解这种人群中ND背后的机制对于改善长期结果至关重要.

研究的目的:

使用多组学方法阐明患有先天性心脏病 (CHD) 的儿童的神经发育障碍 (ND) 的机制.
为了确定特定的血清代谢物和与心脏病患者中ND相关的肠道微生物特征.

主要方法:

展望观察性研究分析血清代谢和肠道微生物组在儿童和没有ND内心病患者群体内.
相关性分析以确定代谢物,微生物组成和神经发育结果之间的关联.

主要成果:

临酸被确定为一种关键的血清代谢物,与多个神经发育领域具有积极的相关性.
埃舍里希亚属是最突出的肠道微生物,与神经发育结果负相关.
在患有心血管疾病的儿童中,在改变的血清代谢物,肠道微生物群失调和ND之间发现了显著的关联.

结论:

这项多学科研究强调了小儿心血管疾病中肠道微生物组,血清代谢组和神经发育结果之间的复杂关系.
已识别的微生物和代谢物为治疗策略提供了潜在的目标,以减轻心脏病患者的ND风险.
未来的干预措施可以专注于对肠道微生物群和特定代谢物进行有针对性的操纵,以改善神经发育轨迹.

关键词:

遗传性心脏病是一种先天性心脏病.我们的肠道微生物群.婴儿婴儿婴儿婴儿代谢产物的代谢产物神经发育障碍神经发育障碍

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