系统性免疫炎症指数与潜伏性结核感染之间的关联:一个横截面研究
Ting Pang1, Lei Wang1, Jie Zhang1
1Department of Infectious Diseases, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Frontiers in medicine
|August 14, 2025
概括
系统性免疫炎症指数 (SII) 与美国成年人潜在结核感染 (LTBI) 相反相关. 较高的SII水平与较低的LTBI可能性相关,表明其作为风险分层标志物的潜力.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 系统性免疫炎症指数 (SII) 与各种疾病有关.
- 目前尚不清楚SII和潜伏性结核感染 (LTBI) 之间的关联.
研究的目的:
- 在美国成年人群中调查SII和LTBI之间的关系.
- 确定SII是否可以用于LTBI风险分层.
主要方法:
- 利用了1999-2000年和2011-2012年国家健康和营养检查调查 (NHANES) 的数据.
- 通过使用QuantiFERON-TB Gold (QFT-GIT) 或结核素皮肤测试 (TST) 确定了LTBI.
- 从中性粒细胞,血小板和淋巴细胞计数计算SII;采用多变量逻辑回归和受限立方线.
主要成果:
- 总共有9,489名参与者被分析,其中1,068人患有LTBI.
- SII与LTBI相反相关;每增加100个单位的SII将LTBI赔率降低6% (aOR=0.94).
- 在最高的SII四分位数中的参与者具有显著较低的LTBI几率 (aOR=0.58),具有线性趋势 (P=0.003).
结论:
- SII显示了与LTBI的反向关联.
- SII可以作为LTBI风险分层的可访问标记.
- 建议进行进一步的纵向研究,以确认临床效用.
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