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为系统生物学应用绘制肠道微生物群依赖的三甲基胺N-氧化物超级通路

Isabel M E Valenbreder¹, Sonia Balăn¹, Marian Breuer¹

¹Maastricht Centre for Systems Biology (MaCSBio), Maastricht University, Maastricht, Netherlands.

Frontiers in systems biology

|August 14, 2025

概括

肠心轴涉及肠道微生物产生的三甲基胺/三甲基胺N氧化物 (TMA/TMAO),影响心脏健康. 系统生物学和途径映射增强了对这种代谢联系及其在心血管疾病中的作用的理解.

科学领域:

微生物学微生物学
代谢工程是代谢工程.
心血管研究研究心血管研究

背景情况:

肠道微生物群和心脏通过代谢轴联系在一起.
来自肠道微生物群的三甲基胺/三甲基胺N-氧化物 (TMA/TMAO) 途径在心血管健康和疾病进展中起作用.
系统生物学方法为肠心轴代谢提供了新的见解.

研究的目的:

审查目前关于TMA/TMAO代谢途径的研究结果.
在WikiPathways上展示TMA/TMAO路径的策划路径地图.
突出路径图对于系统生物学建模和理解肠心轴的有用性.

主要方法:

关于TMA/TMAO通路的最新发现的文献综述.
在WikiPathways上创建一个策划的路径地图.
讨论系统生物学对代谢建模的应用.

主要成果:

提供了关于TMA/TMAO超级通路的最新研究概述.
在WikiPathways上提供了TMA/TMAO路径的策划路径地图.
路径地图作为社区策划和系统生物学建模的资源.

结论:

策划的TMA/TMAO路径地图有助于理解肠心轴.
路径图可以集成到全身代谢模型中进行计算模拟.
这种方法可以推动研究TMA/TMAO途径在心血管代谢中的作用.

关键词:

在TMA/TMAO路径上.基于约束的建模.我们的肠道微生物组.肠心轴 - 肠心轴 - 肠心轴心脏衰竭是因为心脏衰竭.路径路径路径路径路径全身代谢模型的整体代谢模型.

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