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单剂量迷幻药在给药后几周后在小鼠中增强了认知灵活性和逆转学习

Elizabeth J Brouns¹, Tyler G Ekins^1,2, Omar J Ahmed^1,2,3,4,5

¹Department of Psychology, University of Michigan, Ann Arbor, MI 48109.

Psychedelics

|August 14, 2025

概括

一次剂量的迷幻化合物25CN-NBOH显著改善了小鼠的认知灵活性,持续了数周. 这表明,通过增强大脑可塑性,有可能治疗抑郁症和PTSD等疾病.

科学领域:

神经科学是一个神经科学.
心理药理学心理药理学
认知科学认知科学

背景情况:

神经精神疾病通常涉及认知灵活性受损,这是前额叶皮层 (PFC) 关键功能.
迷幻化合物通过促进神经可塑性显示出治疗这些疾病的潜力.
认知刚性是诸如抑郁症,PTSD和神经退行性疾病等疾病的标志.

研究的目的:

调查选择性血清素2A受体激动剂25CN-NBOH对认知灵活性的长期影响.
在认知障碍模型中评估迷幻药的治疗潜力.

主要方法:

一次给予25CN-NBOH的雄性和雌性小鼠.
利用一种新的自动化顺序学习模式来评估认知灵活性.
测量行为结果,包括效率,试验准确性和奖励获取治疗后2-3周.

主要成果:

与对照组相比,接受迷幻药治疗的小鼠在认知灵活性方面表现出显著而持续的改善.
在规则反转任务中观察到更强的适应性,提高了点击效率和正确的试验.
一次剂量后,行为上的好处持续了数周,与PFC中已知的迷幻诱导的结构重塑有关.

结论:

一次剂量25CN-NBOH在小鼠中提供长期的认知灵活性益处.
这些发现支持了迷幻药在以认知刚性为特征的疾病中的治疗潜力.
自动行为任务提供了一种可扩展的方法来评估迷幻药对认知灵活性的影响.

关键词:

认知灵活性认知灵活性神经可塑性神经可塑性迷幻疗法是一种心理治疗.逆向学习是一种反向学习.血清素2a受体的受体

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