允许在体内比较不同的四维磁共振成像序列,用于使用视觉生物反来指导放射治疗
Katrinus Keijnemans1, Tim Schakel1, Bastien Lecoeur2,3
1Department of Radiotherapy, University Medical Center Utrecht, Heidelberglaan 100, Utrecht, 3584 CX, The Netherlands.
Physics and imaging in radiation oncology
|August 14, 2025
概括
使用四维MRI (4D-MRI) 的视觉生物反 (VBF) 通过减少呼吸变化和运动幅度差异来改善放射治疗序列的体内比较. 这种技术增强了适应性放射治疗的解剖学一致性.
科学领域:
- 医疗成像医学成像
- 放射治疗 物理 物理
- 生物医学工程 生物医学工程
背景情况:
- 控制呼吸运动对于有效的腹腔胸部放射治疗至关重要.
- 四维MRI (4D-MRI) 有助于通过估计运动来定义适应性放射治疗的治疗量.
- 在体内验证4D-MRI序列是具有挑战性的,因为呼吸的可变性.
研究的目的:
- 将视觉生物反 (VBF) 与4D-MRI序列相结合,以改善体内比较.
- 评估VBF对呼吸变异性和运动幅度估计的影响.
- 为了促进不同4D-MRI采集技术的更可靠的比较.
主要方法:
- 14名健康志愿者和1名患者接受了1.5T的MRI-linac扫描.
- 获得的辐射星堆 (SoS),同时多切片 (SMS) 和卡特西亚 (CASPR) 4D-MRI 序列.
- 应用VBF使用1D呼吸导航器 (1D-RNAV) 在获取过程中指导呼吸.
主要成果:
- VBF 减少了 37% (幅度) 和 64% (周期) 的呼吸变化.
- 4D-MRI运动幅度的志愿者内部协议中位数从VBF的3.5毫米提高到1.8毫米.
- 与呼吸波形相比,4D-MRI衍生的振幅显示了 -31% (SoS), -17% (SMS) 和 -9% (CASPR) 的中间差异.
结论:
- 以VBF为指导的4D-MRI方法允许对MRI序列进行可靠的体内比较.
- 这种方法提高了适应性放射治疗规划的解剖学一致性.
- 改进的比较方便了为临床使用选择最佳的4D-MRI技术.
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